Background: There is a growing need for analyzing medical data such as brain connectomes. However, the unavailability of large-scale training samples increases risks of model over-fitting. Recently, deep learning (DL) architectures quickly gained momentum in synthesizing medical data. However, such frameworks are primarily designed for Euclidean data (eg., images), overlooking geometric data (eg., brain connectomes). A few existing geometric DL works that aimed to predict a target brain connectome from a source one primarily focused on domain alignment and were agnostic to preserving the connectome topology.
New Method: To address the above limitations, firstly, we adapt the graph translation generative adversarial network (GT GAN) architecture to brain connectomic data. Secondly, we extend the baseline GT GAN to a cyclic graph translation (CGT) GAN, allowing bidirectional brain network translation between the source and target views. Finally, to preserve the topological strength of brain regions of interest (ROIs), we impose a topological strength constraint on the CGT GAN learning, thereby introducing CGTS GAN architecture.
Comparison with existing methods: We compared CGTS with graph translation methods and its ablated versions.
Results: Our deep graph network outperformed the baseline comparison method and its ablated versions in mean squared error (MSE) using multiview autism spectrum disorder connectomic dataset.
Conclusion: We designed a topology-aware bidirectional brain connectome synthesis framework rooted in geometric deep learning, which can be used for data augmentation in clinical diagnosis.
- Brain connectome generation
- Cyclic adversarial graph translation
- Geometric deep learning
- Topological strength