Topology-Guided Cyclic Brain Connectivity Generation using Geometric Deep Learning

Abubakhari Sserwadda, Islem Rekik (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
109 Downloads (Pure)


Background: There is a growing need for analyzing medical data such as brain connectomes. However, the unavailability of large-scale training samples increases risks of model over-fitting. Recently, deep learning (DL) architectures quickly gained momentum in synthesizing medical data. However, such frameworks are primarily designed for Euclidean data (eg., images), overlooking geometric data (eg., brain connectomes). A few existing geometric DL works that aimed to predict a target brain connectome from a source one primarily focused on domain alignment and were agnostic to preserving the connectome topology.

New Method: To address the above limitations, firstly, we adapt the graph translation generative adversarial network (GT GAN) architecture to brain connectomic data. Secondly, we extend the baseline GT GAN to a cyclic graph translation (CGT) GAN, allowing bidirectional brain network translation between the source and target views. Finally, to preserve the topological strength of brain regions of interest (ROIs), we impose a topological strength constraint on the CGT GAN learning, thereby introducing CGTS GAN architecture.

Comparison with existing methods: We compared CGTS with graph translation methods and its ablated versions.

Results: Our deep graph network outperformed the baseline comparison method and its ablated versions in mean squared error (MSE) using multiview autism spectrum disorder connectomic dataset.

Conclusion: We designed a topology-aware bidirectional brain connectome synthesis framework rooted in geometric deep learning, which can be used for data augmentation in clinical diagnosis.

Original languageEnglish
Article number108988
Number of pages11
JournalJournal of Neuroscience Methods
Early online date4 Nov 2020
Publication statusPublished - 1 Apr 2021


  • Brain connectome generation
  • Cyclic adversarial graph translation
  • Geometric deep learning
  • Topological strength

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Topology-Guided Cyclic Brain Connectivity Generation using Geometric Deep Learning'. Together they form a unique fingerprint.

Cite this