Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

Hollie A. Clements; Tim J. Underwood; Russell D. Petty

doi:10.1038/s41416-023-02458-w

Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

Hollie A. Clements (Lead / Corresponding author), Tim J. Underwood, Russell D. Petty

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

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Abstract

Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

Original language	English
Pages (from-to)	9-18
Number of pages	10
Journal	British Journal of Cancer
Volume	130
Issue number	1
Early online date	28 Oct 2023
DOIs	https://doi.org/10.1038/s41416-023-02458-w
Publication status	Published - 31 Jan 2024

Keywords

Oesophageal cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41416-023-02458-wLicence: CC BY

Final Published VersionFinal published version, 432 KBLicence: CC BY

Cite this

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title = "Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma",

abstract = "Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.",

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AU - Clements, Hollie A.

AU - Underwood, Tim J.

AU - Petty, Russell D.

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Y1 - 2024/1/31

N2 - Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

AB - Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

KW - Oesophageal cancer

U2 - 10.1038/s41416-023-02458-w

DO - 10.1038/s41416-023-02458-w

M3 - Review article

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JF - British Journal of Cancer

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ER -

Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

Abstract

Keywords

UN SDGs

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