Total neoadjuvant therapy in oesophageal and gastro-oesophageal junctional adenocarcinoma

Hollie A. Clements (Lead / Corresponding author), Tim J. Underwood, Russell D. Petty

Research output: Contribution to journalReview articlepeer-review

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Adenocarcinoma of the oesophagus and gastro-oesophageal junction represent a large burden of cancer death in the Western World with an increasing incidence. In the past two decades, the overall survival of patients on a potentially curative treatment pathway has more than doubled due to the addition of perioperative oncological therapies to surgery. However, patients often fail to respond to oncological treatment or struggle to complete their treatment after surgery. In this review, we discuss the current evidence for total neoadjuvant therapy and options for assessment of treatment response.

Original languageEnglish
Pages (from-to)9-18
Number of pages10
JournalBritish Journal of Cancer
Issue number1
Early online date28 Oct 2023
Publication statusPublished - 31 Jan 2024


  • Oesophageal cancer


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