Toward a high-resolution view of nuclear dynamics

Laura Trinkle-Mulcahy, Angus I. Lamond

    Research output: Contribution to journalArticle

    56 Citations (Scopus)

    Abstract

    The nucleus is the defining feature of eukaryotic cells. It is a highly dynamic, membrane-bound organelle that encloses chromatin and thereby partitions gene transcription from sites of protein translation in the cytoplasm. Major cellular events, including DNA replication, messenger RNA synthesis and processing, and ribosome subunit biogenesis, take place within the nucleus, resulting in a continuous flux of macromolecules into and out of the nucleus through dedicated nuclear pore complexes in the nuclear envelope. Here, we review the impact of new technologies, especially in areas of fluorescence microscopy and proteomics, which are providing major insights into dynamic processes affecting both structure and function within the nucleus.
    Original languageEnglish
    Pages (from-to)1402-1407
    Number of pages6
    JournalScience
    Volume318
    Issue number5855
    DOIs
    Publication statusPublished - 2007

    Keywords

    • Active Transport, Cell Nucleus
    • Animals
    • Cell Nucleolus
    • Cell Nucleus
    • Cell Nucleus Structures
    • Microscopy, Fluorescence
    • Mitosis
    • Nuclear Envelope
    • Nuclear Pore
    • Nuclear Proteins
    • Proteomics

    Fingerprint Dive into the research topics of 'Toward a high-resolution view of nuclear dynamics'. Together they form a unique fingerprint.

  • Cite this