Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells

Severine Grouffaud, Stephen C. Whisson, Paul R. J. Birch, Pieter van West

    Research output: Contribution to journalReview article

    9 Citations (Scopus)

    Abstract

    The most notorious oomycetes, such as Phytophthora infestans, are pathogens of higher plants, although numerous other species of these fungal-like microorganisms infect algae, crustacea, nematodes, fish and mammals. While there is now ample evidence that oomycetes and fungi deliver effector proteins inside the host cell during infection, like bacteria using the well characterised type III secretion system, the mechanism employed by eukaryotic pathogens remains unclear. In oomycetes this process depends on an N-terminal motif defined by a short conserved amino acid sequence (RxLR) located near the signal peptide of many secreted proteins. This motif resembles the host-cell targeting signal found in virulence proteins from the malaria parasite Plasmodium falciparum (RxLxE/D/Q).

    This review will focus on the recent findings contributing to the understanding of the delivery of oomycete effector molecules into the host cells, with emphasis on how they compare with various models proposed for filamentous fungi and the malaria parasite.
    Original languageEnglish
    Pages (from-to)27-36
    JournalFungal Biology Reviews
    Volume24
    Issue number1-2
    DOIs
    Publication statusPublished - 2010

    Fingerprint

    Oomycetes
    Parasites
    Proteins
    Fungi
    Phytophthora infestans
    Crustacea
    Falciparum Malaria
    Protein Sorting Signals
    Malaria
    Virulence
    Mammals
    Amino Acid Sequence
    Fishes
    Bacteria
    Infection

    Keywords

    • Effector
    • Malaria
    • Oomycete
    • PEXEL
    • Phytophthora
    • Plasmodium
    • RxLR

    Cite this

    Grouffaud, Severine ; Whisson, Stephen C. ; Birch, Paul R. J. ; West, Pieter van. / Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells. In: Fungal Biology Reviews. 2010 ; Vol. 24, No. 1-2. pp. 27-36.
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    title = "Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells",
    abstract = "The most notorious oomycetes, such as Phytophthora infestans, are pathogens of higher plants, although numerous other species of these fungal-like microorganisms infect algae, crustacea, nematodes, fish and mammals. While there is now ample evidence that oomycetes and fungi deliver effector proteins inside the host cell during infection, like bacteria using the well characterised type III secretion system, the mechanism employed by eukaryotic pathogens remains unclear. In oomycetes this process depends on an N-terminal motif defined by a short conserved amino acid sequence (RxLR) located near the signal peptide of many secreted proteins. This motif resembles the host-cell targeting signal found in virulence proteins from the malaria parasite Plasmodium falciparum (RxLxE/D/Q).This review will focus on the recent findings contributing to the understanding of the delivery of oomycete effector molecules into the host cells, with emphasis on how they compare with various models proposed for filamentous fungi and the malaria parasite.",
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    author = "Severine Grouffaud and Whisson, {Stephen C.} and Birch, {Paul R. J.} and West, {Pieter van}",
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    Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells. / Grouffaud, Severine; Whisson, Stephen C.; Birch, Paul R. J.; West, Pieter van.

    In: Fungal Biology Reviews, Vol. 24, No. 1-2, 2010, p. 27-36.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Towards an understanding on how RxLR-effector proteins are translocated from oomycetes into host cells

    AU - Grouffaud, Severine

    AU - Whisson, Stephen C.

    AU - Birch, Paul R. J.

    AU - West, Pieter van

    PY - 2010

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    N2 - The most notorious oomycetes, such as Phytophthora infestans, are pathogens of higher plants, although numerous other species of these fungal-like microorganisms infect algae, crustacea, nematodes, fish and mammals. While there is now ample evidence that oomycetes and fungi deliver effector proteins inside the host cell during infection, like bacteria using the well characterised type III secretion system, the mechanism employed by eukaryotic pathogens remains unclear. In oomycetes this process depends on an N-terminal motif defined by a short conserved amino acid sequence (RxLR) located near the signal peptide of many secreted proteins. This motif resembles the host-cell targeting signal found in virulence proteins from the malaria parasite Plasmodium falciparum (RxLxE/D/Q).This review will focus on the recent findings contributing to the understanding of the delivery of oomycete effector molecules into the host cells, with emphasis on how they compare with various models proposed for filamentous fungi and the malaria parasite.

    AB - The most notorious oomycetes, such as Phytophthora infestans, are pathogens of higher plants, although numerous other species of these fungal-like microorganisms infect algae, crustacea, nematodes, fish and mammals. While there is now ample evidence that oomycetes and fungi deliver effector proteins inside the host cell during infection, like bacteria using the well characterised type III secretion system, the mechanism employed by eukaryotic pathogens remains unclear. In oomycetes this process depends on an N-terminal motif defined by a short conserved amino acid sequence (RxLR) located near the signal peptide of many secreted proteins. This motif resembles the host-cell targeting signal found in virulence proteins from the malaria parasite Plasmodium falciparum (RxLxE/D/Q).This review will focus on the recent findings contributing to the understanding of the delivery of oomycete effector molecules into the host cells, with emphasis on how they compare with various models proposed for filamentous fungi and the malaria parasite.

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    KW - Oomycete

    KW - PEXEL

    KW - Phytophthora

    KW - Plasmodium

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    DO - 10.1016/j.fbr.2010.01.002

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    JO - Fungal Biology Reviews

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