Towards monodisperse microbubble populations via microfluidic chip flow-focusing

Yaoyao Cui; Paul A. Campbell

doi:10.1109/ULTSYM.2008.0406

Towards monodisperse microbubble populations via microfluidic chip flow-focusing

Yaoyao Cui, Paul A. Campbell

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Citations (Scopus)

Abstract

Encapsulated ultrasound contrast agents (UCA) have received considerable attention recently, not only because of their echogenic properties which aid diagnostic imaging, but also for their ability to mediate targeted drug and gene delivery. Certain advantages may arise if monodisperse populations of microbubbles can be developed: specifically, an abrupt, well controlled response may be achievable which would lend itself to enhanced delivery efficiencies. In this paper, we highlight the rationale for the development of our own in-house approach to microbubble generation, and set this in the context of some contemporary bubble preparation technologies based on microfludic methods.

Original language	English
Title of host publication	2008 IEEE Ultrasonics Symposium, Vols 1-4 and Appendix
Place of Publication	NEW YORK
Publisher	IEEE Computer Society
Pages	1663-1666
Number of pages	4
ISBN (Print)	978-1-4244-2428-3
DOIs	https://doi.org/10.1109/ULTSYM.2008.0406
Publication status	Published - 2008
Event	2008 IEEE International Ultrasonics Symposium (IUS) - Beijing, China Duration: 2 Nov 2008 → 5 Nov 2008 http://ewh.ieee.org/conf/ius_2008/

Conference

Conference	2008 IEEE International Ultrasonics Symposium (IUS)
Abbreviated title	2008 IEEE IUS
Country/Territory	China
City	Beijing
Period	2/11/08 → 5/11/08
Internet address	http://ewh.ieee.org/conf/ius_2008/

Keywords

Microbubble
flow-focusing
microfludics
medical ultrasound therapy
COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION
COATED MICROBUBBLES
CONTRAST AGENTS
BUBBLES
DEVICE

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10.1109/ULTSYM.2008.0406

Cite this

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title = "Towards monodisperse microbubble populations via microfluidic chip flow-focusing",

abstract = "Encapsulated ultrasound contrast agents (UCA) have received considerable attention recently, not only because of their echogenic properties which aid diagnostic imaging, but also for their ability to mediate targeted drug and gene delivery. Certain advantages may arise if monodisperse populations of microbubbles can be developed: specifically, an abrupt, well controlled response may be achievable which would lend itself to enhanced delivery efficiencies. In this paper, we highlight the rationale for the development of our own in-house approach to microbubble generation, and set this in the context of some contemporary bubble preparation technologies based on microfludic methods.",

keywords = "Microbubble, flow-focusing, microfludics, medical ultrasound therapy, COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION, COATED MICROBUBBLES, CONTRAST AGENTS, BUBBLES, DEVICE",

author = "Yaoyao Cui and Campbell, {Paul A.}",

year = "2008",

doi = "10.1109/ULTSYM.2008.0406",

language = "English",

isbn = "978-1-4244-2428-3",

pages = "1663--1666",

booktitle = "2008 IEEE Ultrasonics Symposium, Vols 1-4 and Appendix",

publisher = "IEEE Computer Society",

note = "2008 IEEE International Ultrasonics Symposium (IUS), 2008 IEEE IUS ; Conference date: 02-11-2008 Through 05-11-2008",

url = "http://ewh.ieee.org/conf/ius_2008/",

}

TY - GEN

T1 - Towards monodisperse microbubble populations via microfluidic chip flow-focusing

AU - Cui, Yaoyao

AU - Campbell, Paul A.

PY - 2008

Y1 - 2008

N2 - Encapsulated ultrasound contrast agents (UCA) have received considerable attention recently, not only because of their echogenic properties which aid diagnostic imaging, but also for their ability to mediate targeted drug and gene delivery. Certain advantages may arise if monodisperse populations of microbubbles can be developed: specifically, an abrupt, well controlled response may be achievable which would lend itself to enhanced delivery efficiencies. In this paper, we highlight the rationale for the development of our own in-house approach to microbubble generation, and set this in the context of some contemporary bubble preparation technologies based on microfludic methods.

AB - Encapsulated ultrasound contrast agents (UCA) have received considerable attention recently, not only because of their echogenic properties which aid diagnostic imaging, but also for their ability to mediate targeted drug and gene delivery. Certain advantages may arise if monodisperse populations of microbubbles can be developed: specifically, an abrupt, well controlled response may be achievable which would lend itself to enhanced delivery efficiencies. In this paper, we highlight the rationale for the development of our own in-house approach to microbubble generation, and set this in the context of some contemporary bubble preparation technologies based on microfludic methods.

KW - Microbubble

KW - flow-focusing

KW - microfludics

KW - medical ultrasound therapy

KW - COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION

KW - COATED MICROBUBBLES

KW - CONTRAST AGENTS

KW - BUBBLES

KW - DEVICE

U2 - 10.1109/ULTSYM.2008.0406

DO - 10.1109/ULTSYM.2008.0406

M3 - Conference contribution

SN - 978-1-4244-2428-3

SP - 1663

EP - 1666

BT - 2008 IEEE Ultrasonics Symposium, Vols 1-4 and Appendix

PB - IEEE Computer Society

CY - NEW YORK

T2 - 2008 IEEE International Ultrasonics Symposium (IUS)

Y2 - 2 November 2008 through 5 November 2008

ER -

Towards monodisperse microbubble populations via microfluidic chip flow-focusing

Abstract

Conference

Keywords

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