Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering

Muthu Rama Krishnan Mookiah; Sarah McGrory; Stephen Hogg; Jackie Price; Rachel Forster; Thomas J. MacGillivray; Emanuele Trucco

doi:10.1007/978-3-030-00949-6_35

Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering

Muthu Rama Krishnan Mookiah, Sarah McGrory, Stephen Hogg, Jackie Price, Rachel Forster, Thomas J. MacGillivray, Emanuele Trucco

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

9 Citations (Scopus)

220 Downloads (Pure)

Abstract

Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters computed from 80 retinal images (20 subjects, right and left eye, optic-disc and macula centered), we find strong variations and limited concordance in images of the two types. Although analysis of larger cohorts is obviously necessary, our results strengthen the need for a structured investigation into the uncertainty of retinal vasculature measurements, ideally in the framework of an international debate on standardization.

Original language	English
Title of host publication	Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings
Editors	Zeike Taylor, Hrvoje Bogunovic, David Snead, Mona K. Garvin, Xin Jan Chen, Francesco Ciompi, Yanwu Xu, Lena Maier-Hein, Mitko Veta, Emanuele Trucco, Danail Stoyanov, Nasir Rajpoot, Jeroen van der Laak, Anne Martel, Stephen McKenna
Publisher	Springer Verlag
Pages	294-302
Number of pages	9
ISBN (Print)	9783030009489
DOIs	https://doi.org/10.1007/978-3-030-00949-6_35
Publication status	Published - 14 Sept 2018
Event	1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018 - Granada, Spain Duration: 16 Sept 2018 → 20 Sept 2018

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	11039 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018
Country/Territory	Spain
City	Granada
Period	16/09/18 → 20/09/18

Keywords

Biomarkers
Microvasculature
Retina
Uncertainty
VAMPIRE

ASJC Scopus subject areas

Theoretical Computer Science
General Computer Science

Access to Document

10.1007/978-3-030-00949-6_35

Author Accepted ManuscriptAccepted author manuscript, 206 KB

Cite this

Mookiah, M. R. K., McGrory, S., Hogg, S., Price, J., Forster, R., MacGillivray, T. J., & Trucco, E. (2018). Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering. In Z. Taylor, H. Bogunovic, D. Snead, M. K. Garvin, X. J. Chen, F. Ciompi, Y. Xu, L. Maier-Hein, M. Veta, E. Trucco, D. Stoyanov, N. Rajpoot, J. van der Laak, A. Martel, & S. McKenna (Eds.), Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings (pp. 294-302). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11039 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-00949-6_35

Mookiah, Muthu Rama Krishnan ; McGrory, Sarah ; Hogg, Stephen et al. / Towards Standardization of Retinal Vascular Measurements : On the Effect of Image Centering. Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. editor / Zeike Taylor ; Hrvoje Bogunovic ; David Snead ; Mona K. Garvin ; Xin Jan Chen ; Francesco Ciompi ; Yanwu Xu ; Lena Maier-Hein ; Mitko Veta ; Emanuele Trucco ; Danail Stoyanov ; Nasir Rajpoot ; Jeroen van der Laak ; Anne Martel ; Stephen McKenna. Springer Verlag, 2018. pp. 294-302 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

@inproceedings{f4ed7fb2b5234be79ec2a4cc0f105f91,

title = "Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering",

abstract = "Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters computed from 80 retinal images (20 subjects, right and left eye, optic-disc and macula centered), we find strong variations and limited concordance in images of the two types. Although analysis of larger cohorts is obviously necessary, our results strengthen the need for a structured investigation into the uncertainty of retinal vasculature measurements, ideally in the framework of an international debate on standardization.",

keywords = "Biomarkers, Microvasculature, Retina, Uncertainty, VAMPIRE",

author = "Mookiah, {Muthu Rama Krishnan} and Sarah McGrory and Stephen Hogg and Jackie Price and Rachel Forster and MacGillivray, {Thomas J.} and Emanuele Trucco",

year = "2018",

month = sep,

day = "14",

doi = "10.1007/978-3-030-00949-6_35",

language = "English",

isbn = "9783030009489",

series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",

publisher = "Springer Verlag",

pages = "294--302",

editor = "Zeike Taylor and Hrvoje Bogunovic and David Snead and Garvin, {Mona K.} and Chen, {Xin Jan} and Francesco Ciompi and Yanwu Xu and Lena Maier-Hein and Mitko Veta and Emanuele Trucco and Danail Stoyanov and Nasir Rajpoot and {van der Laak}, Jeroen and Anne Martel and Stephen McKenna",

booktitle = "Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings",

address = "Germany",

note = "1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018 ; Conference date: 16-09-2018 Through 20-09-2018",

}

Mookiah, MRK, McGrory, S, Hogg, S, Price, J, Forster, R, MacGillivray, TJ & Trucco, E 2018, Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering. in Z Taylor, H Bogunovic, D Snead, MK Garvin, XJ Chen, F Ciompi, Y Xu, L Maier-Hein, M Veta, E Trucco, D Stoyanov, N Rajpoot, J van der Laak, A Martel & S McKenna (eds), Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11039 LNCS, Springer Verlag, pp. 294-302, 1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018, Granada, Spain, 16/09/18. https://doi.org/10.1007/978-3-030-00949-6_35

Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering. / Mookiah, Muthu Rama Krishnan; McGrory, Sarah; Hogg, Stephen et al.
Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. ed. / Zeike Taylor; Hrvoje Bogunovic; David Snead; Mona K. Garvin; Xin Jan Chen; Francesco Ciompi; Yanwu Xu; Lena Maier-Hein; Mitko Veta; Emanuele Trucco; Danail Stoyanov; Nasir Rajpoot; Jeroen van der Laak; Anne Martel; Stephen McKenna. Springer Verlag, 2018. p. 294-302 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11039 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Towards Standardization of Retinal Vascular Measurements

T2 - 1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018

AU - Mookiah, Muthu Rama Krishnan

AU - McGrory, Sarah

AU - Hogg, Stephen

AU - Price, Jackie

AU - Forster, Rachel

AU - MacGillivray, Thomas J.

AU - Trucco, Emanuele

PY - 2018/9/14

Y1 - 2018/9/14

N2 - Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters computed from 80 retinal images (20 subjects, right and left eye, optic-disc and macula centered), we find strong variations and limited concordance in images of the two types. Although analysis of larger cohorts is obviously necessary, our results strengthen the need for a structured investigation into the uncertainty of retinal vasculature measurements, ideally in the framework of an international debate on standardization.

AB - Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters computed from 80 retinal images (20 subjects, right and left eye, optic-disc and macula centered), we find strong variations and limited concordance in images of the two types. Although analysis of larger cohorts is obviously necessary, our results strengthen the need for a structured investigation into the uncertainty of retinal vasculature measurements, ideally in the framework of an international debate on standardization.

KW - Biomarkers

KW - Microvasculature

KW - Retina

KW - Uncertainty

KW - VAMPIRE

UR - http://www.scopus.com/inward/record.url?scp=85053908620&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-00949-6_35

DO - 10.1007/978-3-030-00949-6_35

M3 - Conference contribution

AN - SCOPUS:85053908620

SN - 9783030009489

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 294

EP - 302

BT - Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings

A2 - Taylor, Zeike

A2 - Bogunovic, Hrvoje

A2 - Snead, David

A2 - Garvin, Mona K.

A2 - Chen, Xin Jan

A2 - Ciompi, Francesco

A2 - Xu, Yanwu

A2 - Maier-Hein, Lena

A2 - Veta, Mitko

A2 - Trucco, Emanuele

A2 - Stoyanov, Danail

A2 - Rajpoot, Nasir

A2 - van der Laak, Jeroen

A2 - Martel, Anne

A2 - McKenna, Stephen

PB - Springer Verlag

Y2 - 16 September 2018 through 20 September 2018

ER -

Mookiah MRK, McGrory S, Hogg S, Price J, Forster R, MacGillivray TJ et al. Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering. In Taylor Z, Bogunovic H, Snead D, Garvin MK, Chen XJ, Ciompi F, Xu Y, Maier-Hein L, Veta M, Trucco E, Stoyanov D, Rajpoot N, van der Laak J, Martel A, McKenna S, editors, Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings. Springer Verlag. 2018. p. 294-302. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-030-00949-6_35

Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this