Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering

Muthu Rama Krishnan Mookiah, Sarah McGrory, Stephen Hogg, Jackie Price, Rachel Forster, Thomas J. MacGillivray, Emanuele Trucco

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)
61 Downloads (Pure)

Abstract

Within the general framework of consistent and reproducible morphometric measurements of the retinal vasculature in fundus images, we present a quantitative pilot study of the changes in measurements commonly used in retinal biomarker studies (e.g. caliber-related, tortuosity and fractal dimension of the vascular network) induced by centering fundus image acquisition on either the optic disc or on the macula. To our best knowledge, no such study has been reported so far. Analyzing 149 parameters computed from 80 retinal images (20 subjects, right and left eye, optic-disc and macula centered), we find strong variations and limited concordance in images of the two types. Although analysis of larger cohorts is obviously necessary, our results strengthen the need for a structured investigation into the uncertainty of retinal vasculature measurements, ideally in the framework of an international debate on standardization.

Original languageEnglish
Title of host publicationComputational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings
EditorsZeike Taylor, Hrvoje Bogunovic, David Snead, Mona K. Garvin, Xin Jan Chen, Francesco Ciompi, Yanwu Xu, Lena Maier-Hein, Mitko Veta, Emanuele Trucco, Danail Stoyanov, Nasir Rajpoot, Jeroen van der Laak, Anne Martel, Stephen McKenna
PublisherSpringer Verlag
Pages294-302
Number of pages9
ISBN (Print)9783030009489
DOIs
Publication statusPublished - 14 Sep 2018
Event1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018 - Granada, Spain
Duration: 16 Sep 201820 Sep 2018

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11039 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference1st International Workshop on Computational Pathology, COMPAY 2018 and 5th International Workshop on Ophthalmic Medical Image Analysis, OMIA 2018 Held in Conjunction with MICCAI 2018
CountrySpain
CityGranada
Period16/09/1820/09/18

Keywords

  • Biomarkers
  • Microvasculature
  • Retina
  • Uncertainty
  • VAMPIRE

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  • Cite this

    Mookiah, M. R. K., McGrory, S., Hogg, S., Price, J., Forster, R., MacGillivray, T. J., & Trucco, E. (2018). Towards Standardization of Retinal Vascular Measurements: On the Effect of Image Centering. In Z. Taylor, H. Bogunovic, D. Snead, M. K. Garvin, X. J. Chen, F. Ciompi, Y. Xu, L. Maier-Hein, M. Veta, E. Trucco, D. Stoyanov, N. Rajpoot, J. van der Laak, A. Martel, & S. McKenna (Eds.), Computational Pathology and Ophthalmic Medical Image Analysis - First International Workshop, COMPAY 2018, and 5th International Workshop, OMIA 2018, Held in Conjunction with MICCAI 2018, Proceedings (pp. 294-302). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11039 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-00949-6_35