TRAF4, at the Crossroad between Morphogenesis and Cancer

Adrien Rousseau; Marie-Christine Rio; Fabien Alpy

doi:10.3390/cancers3022734

TRAF4, at the Crossroad between Morphogenesis and Cancer

Adrien Rousseau, Marie-Christine Rio, Fabien Alpy (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.

Original language	English
Pages (from-to)	2734-49
Number of pages	16
Journal	Cancers
Volume	3
Issue number	2
DOIs	https://doi.org/10.3390/cancers3022734
Publication status	Published - 21 Jun 2011

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10.3390/cancers3022734

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abstract = "Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production. ",

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AB - Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.

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TRAF4, at the Crossroad between Morphogenesis and Cancer

Abstract

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