TRAF4, at the Crossroad between Morphogenesis and Cancer

TY - JOUR

T1 - TRAF4, at the Crossroad between Morphogenesis and Cancer

AU - Rousseau, Adrien

AU - Rio, Marie-Christine

AU - Alpy, Fabien

PY - 2011/6/21

Y1 - 2011/6/21

N2 - Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.

AB - Tumor Necrosis Factor Receptor-Associated Factor 4 (TRAF4) is a gene whose expression is altered in cancers. It is overexpressed in a variety of carcinomas of different origins, often as a consequence of amplification. TRAF4 encodes an adaptor protein that belongs to the TRAF protein family. While most TRAF proteins influence immune and inflammation processes, TRAF4 is mainly involved in developmental and morphogenic processes. Interestingly, this protein has been shown to be linked to crucial cellular functions such as cell polarity and the regulation of reactive oxygen species production.

U2 - 10.3390/cancers3022734

DO - 10.3390/cancers3022734

M3 - Article

C2 - 24212830

SN - 2072-6694

VL - 3

SP - 2734

EP - 2749

JO - Cancers

JF - Cancers

IS - 2

ER -