Transcription factor RORα is critical for nuocyte development

See Heng Wong; Jennifer A Walker; Helen E. Jolin; Lesley F Drynan; Emily Hams; Ana Camelo; Jillian L. Barlow; Daniel Neill; Veera Panova; Ute Koch; Freddy  Radtke; Clare S Hardman; You Yi Hwang; Padraic G. Fallon; Andrew N J McKenzie

doi:10.1038/ni.2208

Transcription factor RORα is critical for nuocyte development

See Heng Wong, Jennifer A Walker, Helen E. Jolin, Lesley F Drynan, Emily Hams, Ana Camelo, Jillian L. Barlow, Daniel Neill, Veera Panova, Ute Koch, Freddy Radtke, Clare S Hardman, You Yi Hwang, Padraic G. Fallon, Andrew N J McKenzie (Lead / Corresponding author)

Molecular Microbiology

Research output: Contribution to journal › Article › peer-review

498 Citations (Scopus)

Abstract

Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.

Original language	English
Pages (from-to)	229-236
Number of pages	9
Journal	Nature Immunology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1038/ni.2208
Publication status	Published - 22 Jan 2012

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abstract = "Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.",

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AU - Wong, See Heng

AU - Walker, Jennifer A

AU - Jolin, Helen E.

AU - Drynan, Lesley F

AU - Hams, Emily

AU - Camelo, Ana

AU - Barlow, Jillian L.

AU - Neill, Daniel

AU - Panova, Veera

AU - Koch, Ute

AU - Radtke, Freddy

AU - Hardman, Clare S

AU - Hwang, You Yi

AU - Fallon, Padraic G.

AU - McKenzie, Andrew N J

PY - 2012/1/22

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AB - Nuocytes are essential in innate type 2 immunity and contribute to the exacerbation of asthma responses. Here we found that nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct, previously unknown members of the lymphoid lineage. Nuocytes required interleukin 7 (IL-7), IL-33 and Notch signaling for development in vitro. Pro-T cell progenitors at double-negative stage 1 (DN1) and DN2 maintained nuocyte potential in vitro, although the thymus was not essential for nuocyte development. Notably, the transcription factor RORα was critical for the development of nuocytes and their role in the expulsion of parasitic worms.

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Transcription factor RORα is critical for nuocyte development

Abstract

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