Transcription-independent functions of MYC: regulation of translation and DNA replication

Michael D. Cole, Victoria H. Cowling

    Research output: Contribution to journalReview article

    106 Citations (Scopus)

    Abstract

    MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

    Original languageEnglish
    Pages (from-to)810-815
    Number of pages6
    JournalNature Reviews Molecular Cell Biology
    Volume9
    Issue number10
    DOIs
    Publication statusPublished - Oct 2008

    Keywords

    • RNA-POLYMERASE-II
    • NERVE GROWTH-FACTOR
    • C-MYC
    • MESSENGER-RNA
    • ESSENTIAL COFACTOR
    • PROCESSING FACTORS
    • RIBOSOMAL DNA
    • CAD PROMOTER
    • TRANSFORMATION
    • ACTIVATION

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