Transcription-independent functions of MYC: regulation of translation and DNA replication

Michael D. Cole; Victoria H. Cowling

doi:10.1038/nrm2467

Transcription-independent functions of MYC: regulation of translation and DNA replication

Michael D. Cole, Victoria H. Cowling

Research output: Contribution to journal › Review article › peer-review

128 Citations (Scopus)

Abstract

MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

Original language	English
Pages (from-to)	810-815
Number of pages	6
Journal	Nature Reviews Molecular Cell Biology
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nrm2467
Publication status	Published - Oct 2008

Keywords

RNA-POLYMERASE-II
NERVE GROWTH-FACTOR
C-MYC
MESSENGER-RNA
ESSENTIAL COFACTOR
PROCESSING FACTORS
RIBOSOMAL DNA
CAD PROMOTER
TRANSFORMATION
ACTIVATION

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10.1038/nrm2467

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)
Cowling, V. (Investigator)
3/12/07 → 2/01/14
Project: Research

Cite this

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title = "Transcription-independent functions of MYC: regulation of translation and DNA replication",

abstract = "MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.",

keywords = "RNA-POLYMERASE-II, NERVE GROWTH-FACTOR, C-MYC, MESSENGER-RNA, ESSENTIAL COFACTOR, PROCESSING FACTORS, RIBOSOMAL DNA, CAD PROMOTER, TRANSFORMATION, ACTIVATION",

author = "Cole, {Michael D.} and Cowling, {Victoria H.}",

year = "2008",

month = oct,

doi = "10.1038/nrm2467",

language = "English",

volume = "9",

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journal = "Nature Reviews Molecular Cell Biology",

issn = "1471-0072",

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T1 - Transcription-independent functions of MYC: regulation of translation and DNA replication

AU - Cole, Michael D.

AU - Cowling, Victoria H.

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N2 - MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

AB - MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

KW - RNA-POLYMERASE-II

KW - NERVE GROWTH-FACTOR

KW - C-MYC

KW - MESSENGER-RNA

KW - ESSENTIAL COFACTOR

KW - PROCESSING FACTORS

KW - RIBOSOMAL DNA

KW - CAD PROMOTER

KW - TRANSFORMATION

KW - ACTIVATION

U2 - 10.1038/nrm2467

DO - 10.1038/nrm2467

M3 - Review article

C2 - 18698328

SN - 1471-0072

VL - 9

SP - 810

EP - 815

JO - Nature Reviews Molecular Cell Biology

JF - Nature Reviews Molecular Cell Biology

IS - 10

ER -

Transcription-independent functions of MYC: regulation of translation and DNA replication

Abstract

Keywords

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Projects

Aref#d: 19352. The Mechanism of Myc function in cell proliferation and cancer (Career Development Fellowship)

Cite this