TY - JOUR
T1 - Transcriptional activation of tyrosinase and TRP-I by p53 links UV irradiation to the protective tanning response
AU - Nylander, Karin
AU - Bourdon, Jean-Christophe
AU - Bray, Susan E.
AU - Gibbs, Neil K.
AU - Kay, Richard
AU - Hart, Ian
AU - Hall, Peter A.
PY - 2000
Y1 - 2000
N2 - We are exposed constantly to potentially harmful compounds and radiations. Complex adaptive protective responses have evolved to prevent such agents causing cellular damage, including potentially oncogenic mutation. The p53 tumour suppressor appears to have; a role in coordinating such responses: it is activated by diverse insults and it acts as a transcriptional regulator of downstream genes that facilitate cellular adaptation. Ultraviolet (UV) light is a particularly potent inducer of p53 expression. In addition, UV light induces the production of melanin as a protection against further irradiation-induced damage. This study shows that the promoters of the genes coding for the enzymes crucial in melanin biosynthesis, namely tyrosinase and tyrosinase-related protein-1 (TRP-1), are activated by wild-type p53. Both promoters have p53-responsive elements and are activated in vivo in a dose-dependent manner by wild-type p53, as well as by the p53 homologues p73 alpha and p63 alpha, Copyright (C) 2000 John Wiley & Sons, Ltd.
AB - We are exposed constantly to potentially harmful compounds and radiations. Complex adaptive protective responses have evolved to prevent such agents causing cellular damage, including potentially oncogenic mutation. The p53 tumour suppressor appears to have; a role in coordinating such responses: it is activated by diverse insults and it acts as a transcriptional regulator of downstream genes that facilitate cellular adaptation. Ultraviolet (UV) light is a particularly potent inducer of p53 expression. In addition, UV light induces the production of melanin as a protection against further irradiation-induced damage. This study shows that the promoters of the genes coding for the enzymes crucial in melanin biosynthesis, namely tyrosinase and tyrosinase-related protein-1 (TRP-1), are activated by wild-type p53. Both promoters have p53-responsive elements and are activated in vivo in a dose-dependent manner by wild-type p53, as well as by the p53 homologues p73 alpha and p63 alpha, Copyright (C) 2000 John Wiley & Sons, Ltd.
U2 - 10.1002/(SICI)1096-9896(200001)190:1<39::AID-PATH492>3.0.CO;2-V
DO - 10.1002/(SICI)1096-9896(200001)190:1<39::AID-PATH492>3.0.CO;2-V
M3 - Article
SN - 0022-3417
VL - 190
SP - 39
EP - 46
JO - Journal of Pathology
JF - Journal of Pathology
IS - 1
ER -