Transcriptional regulation of IL-10 and its cell-specific role in vivo

Kirsty F. MacKenzie, Michael J. Pattison, J. Simon C. Arthur

    Research output: Contribution to journalArticlepeer-review

    26 Citations (Scopus)

    Abstract

    IL-10 is an important anti-inflammatory cytokine that plays important roles in controlling inflammatory responses and keeping the immune system in check following activation. Loss of IL-10 function in mice or humans results in the development of inflammatory bowel disease in response to an elevated immune response to the gut flora. IL-10 also acts to prevent excessive inflammation during the course of infection and has been implicated in a variety of autoimmune conditions. In response to inflammatory signals, IL-10 can be produced by a number of immune cells including T cells, B cells, macrophages, and dendritic cells. Distinct mechanisms control the production of IL-10 in these different cells types. In this review, we describe recent studies that have looked at the signaling pathways that regulate IL-10 production in these cells. Given the number of cell types that produce IL-10, it is perhaps not surprising that the in vivo source of IL-10 can vary in different immune models. We also describe how work using conditional IL-10 knockout mice or adoptive transfer of IL-10-deficient cells has begun to further our understanding regarding which specific immune cells are required for IL-10 production in vivo under different conditions.

    Original languageEnglish
    Pages (from-to)315-345
    Number of pages31
    JournalCritical Reviews in Immunology
    Volume34
    Issue number4
    DOIs
    Publication statusPublished - 2014

    Keywords

    • Interleukin 10
    • B10
    • Tr1
    • Macrophage
    • CREB
    • STAT3

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