Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity

M. A. Forwell; M. G. Peel; K. S. Froebel; J. J. Belch; R. N. MacSween; G. P. Sandilands

Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity

M. A. Forwell, M. G. Peel, K. S. Froebel, J. J. Belch, R. N. MacSween, G. P. Sandilands

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Abstract

In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.

Original language	English
Pages (from-to)	63-67
Number of pages	5
Journal	Journal of Clinical & Laboratory Immunology
Volume	20
Issue number	2
Publication status	Published - 1986

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title = "Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity",

abstract = "In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.",

author = "Forwell, {M. A.} and Peel, {M. G.} and Froebel, {K. S.} and Belch, {J. J.} and MacSween, {R. N.} and Sandilands, {G. P.}",

year = "1986",

language = "English",

volume = "20",

pages = "63--67",

journal = "Journal of Clinical & Laboratory Immunology",

issn = "0141-2760",

publisher = "Teviot Scientific Publications Ltd.",

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TY - JOUR

T1 - Transfusion-induced, Fc gamma-receptor-blocking antibodies

T2 - spectrum of cellular reactivity

AU - Forwell, M. A.

AU - Peel, M. G.

AU - Froebel, K. S.

AU - Belch, J. J.

AU - MacSween, R. N.

AU - Sandilands, G. P.

PY - 1986

Y1 - 1986

N2 - In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.

AB - In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.

M3 - Article

C2 - 2942693

SN - 0141-2760

VL - 20

SP - 63

EP - 67

JO - Journal of Clinical & Laboratory Immunology

JF - Journal of Clinical & Laboratory Immunology

IS - 2

ER -

Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity

Abstract

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