In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.
|Number of pages||5|
|Journal||Journal of Clinical & Laboratory Immunology|
|Publication status||Published - 1986|
Forwell, M. A., Peel, M. G., Froebel, K. S., Belch, J. J., MacSween, R. N., & Sandilands, G. P. (1986). Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity. Journal of Clinical & Laboratory Immunology, 20(2), 63-67. http://www.ncbi.nlm.nih.gov/pubmed/2942693