Transfusion-induced, Fc gamma-receptor-blocking antibodies: spectrum of cellular reactivity

TY - JOUR

T1 - Transfusion-induced, Fc gamma-receptor-blocking antibodies

T2 - spectrum of cellular reactivity

AU - Forwell, M. A.

AU - Peel, M. G.

AU - Froebel, K. S.

AU - Belch, J. J.

AU - MacSween, R. N.

AU - Sandilands, G. P.

PY - 1986

Y1 - 1986

N2 - In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.

AB - In this study we have shown that transfusion-induced Fc gamma R-blocking antibodies have the capacity to react with various cell types which are known to possess this receptor i.e., lymphocytes (T and B cells), polymorphs and platelets. In contrast we were unable to demonstrate any reactivity with K (or NK) lymphocytes or with monocytes. The spectrum of cellular reactivity exhibited by these antibodies suggests that their effect on the immune system may be complex.

M3 - Article

C2 - 2942693

SN - 0141-2760

VL - 20

SP - 63

EP - 67

JO - Journal of Clinical & Laboratory Immunology

JF - Journal of Clinical & Laboratory Immunology

IS - 2

ER -