Abstract
This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide-binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.
| Original language | English |
|---|---|
| Pages (from-to) | 20-27 |
| Number of pages | 8 |
| Journal | Nature Reviews Immunology |
| Volume | 2 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology