Transgenic analysis of thymocyte signal transduction

Doreen A. Cantrell (Lead / Corresponding author)

    Research output: Contribution to journalReview article

    43 Citations (Scopus)

    Abstract

    This review examines the value of transgenic studies in mice for the genetic dissection of signal-transduction pathways relevant to thymus development. T-cell development in the thymus is controlled by an ordered sequence of differentiation and proliferation checkpoints that culminate in the production of correctly selected, non-autoreactive, peripheral T lymphocytes. Work in transgenic mice has been fundamental for the preparation of genetic maps of signal-transduction pathways that control T-cell development. This review discusses how tyrosine kinases, guanine-nucleotide-binding proteins and transcription factors converge to control T-cell differentiation and proliferation in the immune system.

    Original languageEnglish
    Pages (from-to)20-27
    Number of pages8
    JournalNature Reviews Immunology
    Volume2
    Issue number1
    DOIs
    Publication statusPublished - Jan 2002

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