Translation regulation in response to stress

Thomas D. Williams (Lead / Corresponding author), Adrien Rousseau

Research output: Contribution to journalReview articlepeer-review

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Abstract

Cell stresses occur in a wide variety of settings: in disease, during industrial processes, and as part of normal day-to-day rhythms. Adaptation to these stresses requires cells to alter their proteome. Cells modify the proteins they synthesize to aid proteome adaptation. Changes in both mRNA transcription and translation contribute to altered protein synthesis. Here, we discuss the changes in translational mechanisms that occur following the onset of stress, and the impact these have on stress adaptation.

Original languageEnglish
Number of pages21
JournalFEBS Journal
Early online date3 Feb 2024
DOIs
Publication statusE-pub ahead of print - 3 Feb 2024

Keywords

  • mRNA
  • proteostasis
  • signalling
  • stress
  • translation

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Cell Biology

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