Translational control of gene expression via interacting feedback loops

Liang Wang, M. Carmen Romano, Fordyce A. Davidson (Lead / Corresponding author)

Research output: Contribution to journalArticle

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Abstract

Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.
Original languageEnglish
Article number050402
Number of pages5
JournalPhysical Review E: Statistical, Nonlinear, and Soft Matter Physics
Volume100
Issue number5
DOIs
Publication statusPublished - 26 Nov 2019

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gene expression
protein synthesis
cells
proteins
oscillations
synthesis

Keywords

  • Nonlinear Dynamics
  • Interdisciplinary Physics
  • Statistical Physics
  • Biological Physics
  • Networks

Cite this

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Translational control of gene expression via interacting feedback loops. / Wang, Liang; Romano, M. Carmen; Davidson, Fordyce A. (Lead / Corresponding author).

In: Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, Vol. 100, No. 5, 050402, 26.11.2019.

Research output: Contribution to journalArticle

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T1 - Translational control of gene expression via interacting feedback loops

AU - Wang, Liang

AU - Romano, M. Carmen

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KW - Nonlinear Dynamics

KW - Interdisciplinary Physics

KW - Statistical Physics

KW - Biological Physics

KW - Networks

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DO - 10.1103/PhysRevE.100.050402

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JO - Physical Review E: Statistical, Nonlinear, and Soft Matter Physics

JF - Physical Review E: Statistical, Nonlinear, and Soft Matter Physics

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