Translational control of gene expression via interacting feedback loops

Liang Wang, M. Carmen Romano, Fordyce A. Davidson (Lead / Corresponding author)

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Abstract

Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.
Original languageEnglish
Article number050402
Number of pages5
JournalPhysical Review E: Statistical, Nonlinear, and Soft Matter Physics
Volume100
Issue number5
DOIs
Publication statusPublished - 26 Nov 2019

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Keywords

  • Nonlinear Dynamics
  • Interdisciplinary Physics
  • Statistical Physics
  • Biological Physics
  • Networks

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