Translational control of gene expression via interacting feedback loops

TY - JOUR

T1 - Translational control of gene expression via interacting feedback loops

AU - Wang, Liang

AU - Romano, M. Carmen

AU - Davidson, Fordyce A.

PY - 2019/11/26

Y1 - 2019/11/26

N2 - Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.

AB - Translation is a key step in the synthesis of proteins. Accordingly, cells have evolved an intricate array of control mechanisms to regulate this process. By constructing a multicomponent mathematical framework we uncover how translation may be controlled via interacting feedback loops. Our results reveal that this interplay gives rise to a remarkable range of protein synthesis dynamics, including oscillations, step change, and bistability. This suggests that cells may have recourse to a much richer set of control mechanisms than was previously understood.

KW - Nonlinear Dynamics

KW - Interdisciplinary Physics

KW - Statistical Physics

KW - Biological Physics

KW - Networks

U2 - 10.1103/PhysRevE.100.050402

DO - 10.1103/PhysRevE.100.050402

M3 - Article

C2 - 31869996

SN - 1539-3755

VL - 100

JO - Physical Review E: Statistical, nonlinear, and soft matter physics

JF - Physical Review E: Statistical, nonlinear, and soft matter physics

IS - 5

M1 - 050402(R)

ER -