Translational evidence on the role of Src kinase and activated Src kinase in invasive breast cancer

Beatrix Elsberger (Lead / Corresponding author)

    Research output: Contribution to journalArticle

    27 Citations (Scopus)

    Abstract

    Src kinase is a member of a non-receptor tyrosine kinase family. It has been implicated as a regulator of cell proliferation and survival and plays a complex role in cell adhesion and motility. In vitro evidence for a role for Src in breast cancer is compelling. However, only a few translational clinical studies have been undertaken in this field. This review summarises translational evidence on expression and activation of Src kinase in breast cancer patient cohorts exploring clinical significance and the possibility of identifying key biomarkers. There is strengthened translational proof for a definitive role of Src in breast cancer. Nevertheless, there remains a need to find a robust biomarker to identify patients responsive to Src inhibitors for clinical trials.
    Original languageEnglish
    Pages (from-to)343-351
    Number of pages9
    JournalCritical Reviews in Oncology/Hematology
    Volume89
    Issue number3
    DOIs
    Publication statusPublished - Mar 2014

    Fingerprint

    src-Family Kinases
    Breast Neoplasms
    Biomarkers
    Cell Adhesion
    Protein-Tyrosine Kinases
    Cell Movement
    Cell Survival
    Cell Proliferation
    Clinical Trials

    Keywords

    • Src kinase
    • Breast cancer
    • Rranslational research
    • Src kinase inhibitors

    Cite this

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    abstract = "Src kinase is a member of a non-receptor tyrosine kinase family. It has been implicated as a regulator of cell proliferation and survival and plays a complex role in cell adhesion and motility. In vitro evidence for a role for Src in breast cancer is compelling. However, only a few translational clinical studies have been undertaken in this field. This review summarises translational evidence on expression and activation of Src kinase in breast cancer patient cohorts exploring clinical significance and the possibility of identifying key biomarkers. There is strengthened translational proof for a definitive role of Src in breast cancer. Nevertheless, there remains a need to find a robust biomarker to identify patients responsive to Src inhibitors for clinical trials.",
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    Translational evidence on the role of Src kinase and activated Src kinase in invasive breast cancer. / Elsberger, Beatrix (Lead / Corresponding author).

    In: Critical Reviews in Oncology/Hematology, Vol. 89, No. 3, 03.2014, p. 343-351.

    Research output: Contribution to journalArticle

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