Translational Medicine and Patient Safety in Europe: TRANSFoRm - Architecture for the Learning Health System in Europe

Brendan C. Delaney (Lead / Corresponding author), Vasa Curcin, Anna Andreasson, Theodoros N. Arvanitis, Hilde Bastiaens, Derek Corrigan, Jean Francois Ethier, Olga Kostopoulou, Wolfgang Kuchinke, Mark McGilchrist, Paul Van Royen, Peter Wagner

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    Abstract

    The Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care. Methods. The project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath. Results. Four models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case. Conclusions. The project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.

    Original languageEnglish
    Article number961526
    Number of pages8
    JournalBioMed Research International
    Volume2015
    DOIs
    Publication statusPublished - 2015

    Fingerprint

    Translational Medical Research
    Patient Safety
    Medicine
    Health
    Learning
    Research
    Ontology
    Electronic Health Records
    Information Storage and Retrieval
    Evidence-Based Medicine
    Gastroesophageal Reflux
    Chest Pain
    Dyspnea
    Abdominal Pain
    Primary Health Care
    Randomized Controlled Trials
    Medical problems
    Decision support systems
    Genotype
    Interoperability

    Cite this

    Delaney, B. C., Curcin, V., Andreasson, A., Arvanitis, T. N., Bastiaens, H., Corrigan, D., ... Wagner, P. (2015). Translational Medicine and Patient Safety in Europe: TRANSFoRm - Architecture for the Learning Health System in Europe. BioMed Research International, 2015, [961526]. https://doi.org/10.1155/2015/961526
    Delaney, Brendan C. ; Curcin, Vasa ; Andreasson, Anna ; Arvanitis, Theodoros N. ; Bastiaens, Hilde ; Corrigan, Derek ; Ethier, Jean Francois ; Kostopoulou, Olga ; Kuchinke, Wolfgang ; McGilchrist, Mark ; Royen, Paul Van ; Wagner, Peter. / Translational Medicine and Patient Safety in Europe : TRANSFoRm - Architecture for the Learning Health System in Europe. In: BioMed Research International. 2015 ; Vol. 2015.
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    title = "Translational Medicine and Patient Safety in Europe: TRANSFoRm - Architecture for the Learning Health System in Europe",
    abstract = "The Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care. Methods. The project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath. Results. Four models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case. Conclusions. The project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.",
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    Delaney, BC, Curcin, V, Andreasson, A, Arvanitis, TN, Bastiaens, H, Corrigan, D, Ethier, JF, Kostopoulou, O, Kuchinke, W, McGilchrist, M, Royen, PV & Wagner, P 2015, 'Translational Medicine and Patient Safety in Europe: TRANSFoRm - Architecture for the Learning Health System in Europe', BioMed Research International, vol. 2015, 961526. https://doi.org/10.1155/2015/961526

    Translational Medicine and Patient Safety in Europe : TRANSFoRm - Architecture for the Learning Health System in Europe. / Delaney, Brendan C. (Lead / Corresponding author); Curcin, Vasa; Andreasson, Anna; Arvanitis, Theodoros N.; Bastiaens, Hilde; Corrigan, Derek; Ethier, Jean Francois; Kostopoulou, Olga; Kuchinke, Wolfgang; McGilchrist, Mark; Royen, Paul Van; Wagner, Peter.

    In: BioMed Research International, Vol. 2015, 961526, 2015.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Translational Medicine and Patient Safety in Europe

    T2 - TRANSFoRm - Architecture for the Learning Health System in Europe

    AU - Delaney, Brendan C.

    AU - Curcin, Vasa

    AU - Andreasson, Anna

    AU - Arvanitis, Theodoros N.

    AU - Bastiaens, Hilde

    AU - Corrigan, Derek

    AU - Ethier, Jean Francois

    AU - Kostopoulou, Olga

    AU - Kuchinke, Wolfgang

    AU - McGilchrist, Mark

    AU - Royen, Paul Van

    AU - Wagner, Peter

    PY - 2015

    Y1 - 2015

    N2 - The Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care. Methods. The project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath. Results. Four models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case. Conclusions. The project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.

    AB - The Learning Health System (LHS) describes linking routine healthcare systems directly with both research translation and knowledge translation as an extension of the evidence-based medicine paradigm, taking advantage of the ubiquitous use of electronic health record (EHR) systems. TRANSFoRm is an EU FP7 project that seeks to develop an infrastructure for the LHS in European primary care. Methods. The project is based on three clinical use cases, a genotype-phenotype study in diabetes, a randomised controlled trial with gastroesophageal reflux disease, and a diagnostic decision support system for chest pain, abdominal pain, and shortness of breath. Results. Four models were developed (clinical research, clinical data, provenance, and diagnosis) that form the basis of the projects approach to interoperability. These models are maintained as ontologies with binding of terms to define precise data elements. CDISC ODM and SDM standards are extended using an archetype approach to enable a two-level model of individual data elements, representing both research content and clinical content. Separate configurations of the TRANSFoRm tools serve each use case. Conclusions. The project has been successful in using ontologies and archetypes to develop a highly flexible solution to the problem of heterogeneity of data sources presented by the LHS.

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