Translocation renal cell carcinomas: an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors

Richard M. Bambury, Jodie E. Battley, Aoife McCarthy, Claire Brady, Seamus O'Reilly, Paul J. Kelly, Frank O'Brien, Paul Sweeney, Stewart Fleming, Nick J. Mayer, Derek G. Power

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Translocation renal cell carcinomas (tRCC) are a novel, rare, and distinct clinicopathologic entity first described in 2001. They are caused by genetic translocations which fuse transcription factor genes, TFE3 or TFEB, with a promoter region leading to overexpression of the transcription factor. TFE3 and TFEB are members of the MiT family of transcription factors. Other tumors also driven by overexpression of members of the MiT family include alveolar soft part sarcoma, clear cell sarcoma and 30%-40% of melanomas. Recently some authors have suggested classifying these tumors along with tRCC as the 'MiT family of cancers.' We report 3 cases of this rare subtype of renal cell carcinoma and provide an up to date literature review of the topic. This report highlights the clinical and pathologic heterogeneity of these tumors. Efforts are under way to find a therapy to target the gene fusion products or their downstream effectors which drive growth of these tumors.
    Original languageEnglish
    Pages (from-to)357-361
    Number of pages5
    JournalClinical Genitourinary Cancer
    Volume11
    Issue number3
    DOIs
    Publication statusPublished - Sep 2013

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    Microphthalmia-Associated Transcription Factor
    Renal Cell Carcinoma
    Transcription Factors
    Neoplasms
    Alveolar Soft Part Sarcoma
    Clear Cell Sarcoma
    Genetic Translocation
    Gene Fusion
    Genetic Promoter Regions
    Melanoma
    Growth
    Genes

    Cite this

    Bambury, Richard M. ; Battley, Jodie E. ; McCarthy, Aoife ; Brady, Claire ; O'Reilly, Seamus ; Kelly, Paul J. ; O'Brien, Frank ; Sweeney, Paul ; Fleming, Stewart ; Mayer, Nick J. ; Power, Derek G. / Translocation renal cell carcinomas : an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors. In: Clinical Genitourinary Cancer. 2013 ; Vol. 11, No. 3. pp. 357-361.
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    abstract = "Translocation renal cell carcinomas (tRCC) are a novel, rare, and distinct clinicopathologic entity first described in 2001. They are caused by genetic translocations which fuse transcription factor genes, TFE3 or TFEB, with a promoter region leading to overexpression of the transcription factor. TFE3 and TFEB are members of the MiT family of transcription factors. Other tumors also driven by overexpression of members of the MiT family include alveolar soft part sarcoma, clear cell sarcoma and 30{\%}-40{\%} of melanomas. Recently some authors have suggested classifying these tumors along with tRCC as the 'MiT family of cancers.' We report 3 cases of this rare subtype of renal cell carcinoma and provide an up to date literature review of the topic. This report highlights the clinical and pathologic heterogeneity of these tumors. Efforts are under way to find a therapy to target the gene fusion products or their downstream effectors which drive growth of these tumors.",
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    Bambury, RM, Battley, JE, McCarthy, A, Brady, C, O'Reilly, S, Kelly, PJ, O'Brien, F, Sweeney, P, Fleming, S, Mayer, NJ & Power, DG 2013, 'Translocation renal cell carcinomas: an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors', Clinical Genitourinary Cancer, vol. 11, no. 3, pp. 357-361. https://doi.org/10.1016/j.clgc.2012.12.006

    Translocation renal cell carcinomas : an evolving entity and a member of the microphthalmia transcription factor-associated family of tumors. / Bambury, Richard M.; Battley, Jodie E.; McCarthy, Aoife; Brady, Claire; O'Reilly, Seamus; Kelly, Paul J.; O'Brien, Frank; Sweeney, Paul; Fleming, Stewart; Mayer, Nick J.; Power, Derek G.

    In: Clinical Genitourinary Cancer, Vol. 11, No. 3, 09.2013, p. 357-361.

    Research output: Contribution to journalArticle

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    AU - Brady, Claire

    AU - O'Reilly, Seamus

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    AU - Mayer, Nick J.

    AU - Power, Derek G.

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