Transport mechanism of a glutamate transporter homologue GltPh

Yurui Ji, Vincent L. G. Postis, Yingying Wang, Mark Bartlam, Adrian Goldman

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.
Original languageEnglish
Pages (from-to)898-904
Number of pages7
JournalBiochemical Society Transactions
Volume14
Issue number3
DOIs
Publication statusPublished - 9 Jun 2016

Keywords

  • aspartate transporter
  • Cl− conductance
  • excitatory amino acid transporters (EAATs)
  • GltPh
  • glutamate transporter
  • Na+ coupling
  • Cell Membranes
  • Excitation & Transport
  • Structural Biology

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