Transport mechanism of a glutamate transporter homologue GltPh

Yurui Ji; Vincent L. G. Postis; Yingying Wang; Mark Bartlam; Adrian Goldman

doi:10.1042/bst20160055

Transport mechanism of a glutamate transporter homologue GltPh

Yurui Ji, Vincent L. G. Postis, Yingying Wang, Mark Bartlam, Adrian Goldman

Drug Discovery Unit

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

Original language	English
Pages (from-to)	898-904
Number of pages	7
Journal	Biochemical Society Transactions
Volume	14
Issue number	3
DOIs	https://doi.org/10.1042/bst20160055
Publication status	Published - 9 Jun 2016

Keywords

aspartate transporter
Cl− conductance
excitatory amino acid transporters (EAATs)
GltPh
glutamate transporter
Na+ coupling
Cell Membranes
Excitation & Transport
Structural Biology

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10.1042/bst20160055

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title = "Transport mechanism of a glutamate transporter homologue GltPh",

abstract = "Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.",

keywords = "aspartate transporter, Cl− conductance, excitatory amino acid transporters (EAATs), GltPh, glutamate transporter, Na+ coupling, Cell Membranes, Excitation & Transport, Structural Biology",

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AU - Ji, Yurui

AU - Postis, Vincent L. G.

AU - Wang, Yingying

AU - Bartlam, Mark

AU - Goldman, Adrian

PY - 2016/6/9

Y1 - 2016/6/9

N2 - Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

AB - Glutamate transporters are responsible for uptake of the neurotransmitter glutamate in mammalian central nervous systems. Their archaeal homologue GltPh, an aspartate transporter isolated from Pyrococcus horikoshii, has been the focus of extensive studies through crystallography, MD simulations and single-molecule FRET (smFRET). Here, we summarize the recent research progress on GltPh, in the hope of gaining some insights into the transport mechanism of this aspartate transporter.

KW - aspartate transporter

KW - Cl− conductance

KW - excitatory amino acid transporters (EAATs)

KW - GltPh

KW - glutamate transporter

KW - Na+ coupling

KW - Cell Membranes

KW - Excitation & Transport

KW - Structural Biology

U2 - 10.1042/bst20160055

DO - 10.1042/bst20160055

M3 - Article

SN - 0300-5127

VL - 14

SP - 898

EP - 904

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 3

ER -

Transport mechanism of a glutamate transporter homologue GltPh

Abstract

Keywords

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