Treatment of depression

Prescription for success?

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A prospective, population-based study which aimed to examine prescribing patterns of antidepressant drugs was performed in Tayside. All dispensed prescriptions for antidepressants in this area of Scotland were recorded on a computerized database, and linked with hospitalization data. Over the 14-month study period, 14 988 (74%) patients were given only tricyclic antidepressants (TCAs), 3571 (18%) were given only selective serotonin reuptake inhibitors (SSRIs) and 1636 (8%) were given both. Seventy-two per cent of patients were given TCAs at a subtherapeutic dose (as defined by a consensus statement on the use of antidepressants) compared with only 8% of patients given SSRIs at a subtherapeutic dose. However, both classes of drugs were given for inadequate durations. No differences were found in the rate of hospitalization for cardiovascular events or convulsions between patients taking TCAs and those taking SSRIs, although there is the possibility that these data may be confounded as a result of SSRls being prescribed in preference to TCAs in at-risk patients. There was an increased risk of hospital admission for acute retention of urine while taking a TCA. Evidence of the ineffective use of antidepressant therapy from this study provides cause for concern. Further research should address the reasons for this prescribing behaviour and seek to determine how the treatment of depression can be made more rational.

Original languageEnglish
Pages (from-to)S7-S10
Number of pages4
JournalPrimary Care Psychiatry
Volume3
Issue numberSuppl. 1
Publication statusPublished - 1997

Fingerprint

Tricyclic Antidepressive Agents
Prescriptions
Antidepressive Agents
Serotonin Uptake Inhibitors
Hospitalization
Therapeutics
Scotland
Seizures
Urine
Databases
Research
Pharmaceutical Preparations
Population

Keywords

  • Dosage
  • Hospitalization
  • Inhibitors
  • Population study
  • Selective serotonin reuptake
  • Tricyclic antidepressants

Cite this

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title = "Treatment of depression: Prescription for success?",
abstract = "A prospective, population-based study which aimed to examine prescribing patterns of antidepressant drugs was performed in Tayside. All dispensed prescriptions for antidepressants in this area of Scotland were recorded on a computerized database, and linked with hospitalization data. Over the 14-month study period, 14 988 (74{\%}) patients were given only tricyclic antidepressants (TCAs), 3571 (18{\%}) were given only selective serotonin reuptake inhibitors (SSRIs) and 1636 (8{\%}) were given both. Seventy-two per cent of patients were given TCAs at a subtherapeutic dose (as defined by a consensus statement on the use of antidepressants) compared with only 8{\%} of patients given SSRIs at a subtherapeutic dose. However, both classes of drugs were given for inadequate durations. No differences were found in the rate of hospitalization for cardiovascular events or convulsions between patients taking TCAs and those taking SSRIs, although there is the possibility that these data may be confounded as a result of SSRls being prescribed in preference to TCAs in at-risk patients. There was an increased risk of hospital admission for acute retention of urine while taking a TCA. Evidence of the ineffective use of antidepressant therapy from this study provides cause for concern. Further research should address the reasons for this prescribing behaviour and seek to determine how the treatment of depression can be made more rational.",
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Treatment of depression : Prescription for success? / MacDonald, T. M.

In: Primary Care Psychiatry, Vol. 3, No. Suppl. 1, 1997, p. S7-S10.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Treatment of depression

T2 - Prescription for success?

AU - MacDonald, T. M.

PY - 1997

Y1 - 1997

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AB - A prospective, population-based study which aimed to examine prescribing patterns of antidepressant drugs was performed in Tayside. All dispensed prescriptions for antidepressants in this area of Scotland were recorded on a computerized database, and linked with hospitalization data. Over the 14-month study period, 14 988 (74%) patients were given only tricyclic antidepressants (TCAs), 3571 (18%) were given only selective serotonin reuptake inhibitors (SSRIs) and 1636 (8%) were given both. Seventy-two per cent of patients were given TCAs at a subtherapeutic dose (as defined by a consensus statement on the use of antidepressants) compared with only 8% of patients given SSRIs at a subtherapeutic dose. However, both classes of drugs were given for inadequate durations. No differences were found in the rate of hospitalization for cardiovascular events or convulsions between patients taking TCAs and those taking SSRIs, although there is the possibility that these data may be confounded as a result of SSRls being prescribed in preference to TCAs in at-risk patients. There was an increased risk of hospital admission for acute retention of urine while taking a TCA. Evidence of the ineffective use of antidepressant therapy from this study provides cause for concern. Further research should address the reasons for this prescribing behaviour and seek to determine how the treatment of depression can be made more rational.

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KW - Hospitalization

KW - Inhibitors

KW - Population study

KW - Selective serotonin reuptake

KW - Tricyclic antidepressants

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JO - Primary Care Psychiatry

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