Importance of the field: Osteoarthritis and hypertension commonly co-exist. Treatment of osteoarthritis in hypertensive patients is a therapeutic challenge due to the adverse effects of some analgesics, especially non-steroidal anti-inflammatory drugs (NSAIDs), on blood pressure. Even small drug-induced rises in blood pressure due to therapy may significantly increase cardiovascular risk in these patients if sustained over the long term. Patients treated with certain classes of antihypertensive agent may be at particular risk of deterioration in blood pressure control with NSAID therapy. NSAIDs may also increase cardiovascular risk due to mechanisms other than by raising blood pressure.
Areas covered in this review: We discuss the management of osteoarthritis in the hypertensive patient, review the evidence for the effects of paracetamol and NSAIDs on blood pressure and discuss novel therapeutic strategies for osteoarthritis that might diminish this problem. A literature search was undertaken in PubMed including the years 1980 - 2009.
What the reader will gain: Insight will be gained into the complexity of treating patients with co-existent osteoarthritis and hypertension and into possible new approaches to treating osteoarthritis symptoms effectively in these patients while minimising any adverse impact on blood pressure control.
Take home message: There are ways to minimise the adverse impact of treatment of osteoarthritis on blood pressure control in hypertensive patients.
- blood pressure
- cyclo-oxygenase inhibiting nitric oxide donators (CINODs)
- nitric oxide
- NONSTEROIDAL ANTIINFLAMMATORY DRUGS
- NITRIC-OXIDE DONATOR
- 24-HOUR BLOOD-PRESSURE
- CORONARY HEART-DISEASE
- CYCLOOXYGENASE-2 INHIBITORS
- GASTROINTESTINAL SAFETY
- WORKING PARTY
- ANALGESIC USE