Treatment of spinal cord injury: a review of engineering using neural and mesenchymal stem cells

Martin M. Mortazavi (Lead / Corresponding author), Olivia A. Harmon, Nimer Adeeb, Aman Deep, R. Shane Tubbs

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Over time, various treatment modalities for spinal cord injury have been trialed, including pharmacological and nonpharmacological methods. Among these, replacement of the injured neural and paraneural tissues via cellular transplantation of neural and mesenchymal stem cells has been the most attractive. Extensive experimental studies have been done to identify the safety and effectiveness of this transplantation in animal and human models. Herein, we review the literature for studies conducted, with a focus on the human-related studies, recruitment, isolation, and transplantation, of these multipotent stem cells, and associated outcomes.
Original languageEnglish
Pages (from-to)37-44
Number of pages8
JournalClinical Anatomy
Volume28
Issue number1
Early online date23 Aug 2014
DOIs
Publication statusPublished - 12 Dec 2014

Keywords

  • stem cell therapy
  • spinal cord injury
  • neural stem cells
  • mesenchymal stem cells
  • anatomy
  • nerve
  • trauma
  • disease
  • pathology
  • stem cells
  • paralysis
  • treatment

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