Treatment of spinal cord injury: a review of engineering using neural and mesenchymal stem cells

Martin M. Mortazavi; Olivia A. Harmon; Nimer Adeeb; Aman Deep; R. Shane Tubbs

doi:10.1002/ca.22443

Treatment of spinal cord injury: a review of engineering using neural and mesenchymal stem cells

Martin M. Mortazavi (Lead / Corresponding author)
, Olivia A. Harmon
, Nimer Adeeb
, Aman Deep
, R. Shane Tubbs

Centre for Anatomy and Human Identification

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Over time, various treatment modalities for spinal cord injury have been trialed, including pharmacological and nonpharmacological methods. Among these, replacement of the injured neural and paraneural tissues via cellular transplantation of neural and mesenchymal stem cells has been the most attractive. Extensive experimental studies have been done to identify the safety and effectiveness of this transplantation in animal and human models. Herein, we review the literature for studies conducted, with a focus on the human-related studies, recruitment, isolation, and transplantation, of these multipotent stem cells, and associated outcomes.

Original language	English
Pages (from-to)	37-44
Number of pages	8
Journal	Clinical Anatomy
Volume	28
Issue number	1
Early online date	23 Aug 2014
DOIs	https://doi.org/10.1002/ca.22443
Publication status	Published - 12 Dec 2014

Keywords

stem cell therapy
spinal cord injury
neural stem cells
mesenchymal stem cells
anatomy
nerve
trauma
disease
pathology
stem cells
paralysis
treatment

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10.1002/ca.22443

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abstract = "Over time, various treatment modalities for spinal cord injury have been trialed, including pharmacological and nonpharmacological methods. Among these, replacement of the injured neural and paraneural tissues via cellular transplantation of neural and mesenchymal stem cells has been the most attractive. Extensive experimental studies have been done to identify the safety and effectiveness of this transplantation in animal and human models. Herein, we review the literature for studies conducted, with a focus on the human-related studies, recruitment, isolation, and transplantation, of these multipotent stem cells, and associated outcomes.",

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AU - Tubbs, R. Shane

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KW - anatomy

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KW - trauma

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Treatment of spinal cord injury: a review of engineering using neural and mesenchymal stem cells

Abstract

Keywords

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