Abstract
Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.
Original language | English |
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Pages (from-to) | 6157-6160 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 51 |
Issue number | 28 |
Early online date | 18 Feb 2015 |
DOIs | |
Publication status | Published - 11 Apr 2015 |
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Catalysis
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry