Triblock peptide-linker-lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

Yuting Liu, Yingying Cai, Wei Liu, Xiao Han Li, Elizabeth Rhoades, Elsa C.Y. Yan (Lead / Corresponding author)

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.

Original languageEnglish
Pages (from-to)6157-6160
Number of pages4
JournalChemical Communications
Volume51
Issue number28
Early online date18 Feb 2015
DOIs
Publication statusPublished - 11 Apr 2015

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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