Triblock peptide-linker-lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

Yuting Liu; Yingying Cai; Wei Liu; Xiao Han Li; Elizabeth Rhoades; Elsa C.Y. Yan

doi:10.1039/c5cc00301f

Triblock peptide-linker-lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

Yuting Liu
, Yingying Cai
, Wei Liu
, Xiao Han Li
, Elizabeth Rhoades
, Elsa C.Y. Yan (Lead / Corresponding author)

Molecular Cell and Developmental Biology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.

Original language	English
Pages (from-to)	6157-6160
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	28
Early online date	18 Feb 2015
DOIs	https://doi.org/10.1039/c5cc00301f
Publication status	Published - 11 Apr 2015

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c5cc00301f

Cite this

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title = "Triblock peptide-linker-lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors",

abstract = "Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.",

author = "Yuting Liu and Yingying Cai and Wei Liu and Li, \{Xiao Han\} and Elizabeth Rhoades and Yan, \{Elsa C.Y.\}",

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AU - Liu, Yuting

AU - Cai, Yingying

AU - Liu, Wei

AU - Li, Xiao Han

AU - Rhoades, Elizabeth

AU - Yan, Elsa C.Y.

PY - 2015/4/11

Y1 - 2015/4/11

N2 - Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.

AB - Two peptide-linker-lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.

UR - https://www.scopus.com/pages/publications/84925583040

U2 - 10.1039/c5cc00301f

DO - 10.1039/c5cc00301f

M3 - Article

C2 - 25748072

SN - 1359-7345

VL - 51

SP - 6157

EP - 6160

JO - Chemical Communications

JF - Chemical Communications

IS - 28

ER -

Triblock peptide-linker-lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

Abstract

ASJC Scopus subject areas

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