Trypanothione metabolism: a chemotherapeutic target in trypanosomatids

G. B. Henderson, A. H. Fairlamb

    Research output: Contribution to journalArticlepeer-review

    35 Citations (Scopus)


    Chemotherapy of trypanosomotid infections continues to present challenges. Treatment of Trypanosoma cruzi infections is virtually impossible, while treatment of Leishmaniasis and African tryponosomiasis is, at best, difficult - often involving toxic drugs based on heavy metals such as antimony and arsenic. As with several other parasites, much recent research has focused on defining metabolic differences between parasite and host that could represent good targets for chemotherapy. As Graeme Henderson and Alan Fairlamb explain, there is something strange about glutothione in trypanosomotids - which seems to offer a very promising chemotherapeutic target.

    Original languageEnglish
    Pages (from-to)312-315
    Number of pages4
    JournalParasitology Today
    Issue number10
    Publication statusPublished - Oct 1987

    ASJC Scopus subject areas

    • Parasitology


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