TSC1-2 tumour suppressor and regulation of mTOR signalling: Linking cell growth and proliferation?

Greg M. Findlay; Laura S. Harrington; Richard F. Lamb

doi:10.1016/j.gde.2004.11.002

TSC1-2 tumour suppressor and regulation of mTOR signalling: Linking cell growth and proliferation?

Greg M. Findlay, Laura S. Harrington, Richard F. Lamb (Lead / Corresponding author)

MRC PPU

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Understanding the relationship between growth and proliferation in multicellular organisms requires identification of the key regulators of growth control, and an understanding of how they regulate growth and how growth is linked to cell proliferation. Recent progress in understanding the mechanisms of growth control indicates that the tuberous sclerosis complex tumour-suppressor TSC1-2 serves as a point of integration between growth-stimulatory and growth-suppressive signalling upstream of a small GTPase, Rheb. However, Rheb-induced growth might not explain the additional effects of TSC1-2 upon cell proliferation.

Original language	English
Pages (from-to)	69-76
Number of pages	8
Journal	Current Opinion in Genetics and Development
Volume	15
Issue number	1
Early online date	30 Nov 2004
DOIs	https://doi.org/10.1016/j.gde.2004.11.002
Publication status	Published - Feb 2005

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2004.11.002

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abstract = "Understanding the relationship between growth and proliferation in multicellular organisms requires identification of the key regulators of growth control, and an understanding of how they regulate growth and how growth is linked to cell proliferation. Recent progress in understanding the mechanisms of growth control indicates that the tuberous sclerosis complex tumour-suppressor TSC1-2 serves as a point of integration between growth-stimulatory and growth-suppressive signalling upstream of a small GTPase, Rheb. However, Rheb-induced growth might not explain the additional effects of TSC1-2 upon cell proliferation.",

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TSC1-2 tumour suppressor and regulation of mTOR signalling: Linking cell growth and proliferation?

Abstract

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