Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment

Alexander R.A. Anderson, Alissa M. Weaver, Peter T. Cummings, Vito Quaranta

    Research output: Contribution to journalArticle

    446 Citations (Scopus)

    Abstract

    Emergence of invasive behavior in cancer is life-threatening, yet ill-defined due to its multifactorial nature. We present a multiscale mathematical model of cancer invasion, which considers cellular and microenvironmental factors simultaneously and interactively. Unexpectedly, the model simulations predict that harsh tumor microenvironment conditions (e.g., hypoxia, heterogenous extracellular matrix) exert a dramatic selective force on the tumor, which grows as an invasive mass with fingering margins, dominated by a few clones with aggressive traits. In contrast, mild microenvironment conditions (e.g., normoxia, homogeneous matrix) allow clones with similar aggressive traits to coexist with less aggressive phenotypes in a heterogeneous tumor mass with smooth, noninvasive margins. Thus, the genetic make-up of a cancer cell may realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces. Our mathematical model provides a theoretical/experimental framework to quantitatively characterize this selective pressure for invasion and test ways to eliminate it.
    Original languageEnglish
    Pages (from-to)905-915
    Number of pages11
    JournalCell
    Volume127
    Issue number5
    DOIs
    Publication statusPublished - 2006

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    Tumors
    Mathematical models
    Neoplasms
    Theoretical Models
    Clone Cells
    Clonal Evolution
    Cells
    Tumor Microenvironment
    Extracellular Matrix
    Phenotype
    indium arsenide

    Cite this

    Anderson, A. R. A., Weaver, A. M., Cummings, P. T., & Quaranta, V. (2006). Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment. Cell, 127(5), 905-915. https://doi.org/10.1016/j.cell.2006.09.042
    Anderson, Alexander R.A. ; Weaver, Alissa M. ; Cummings, Peter T. ; Quaranta, Vito. / Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment. In: Cell. 2006 ; Vol. 127, No. 5. pp. 905-915.
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    abstract = "Emergence of invasive behavior in cancer is life-threatening, yet ill-defined due to its multifactorial nature. We present a multiscale mathematical model of cancer invasion, which considers cellular and microenvironmental factors simultaneously and interactively. Unexpectedly, the model simulations predict that harsh tumor microenvironment conditions (e.g., hypoxia, heterogenous extracellular matrix) exert a dramatic selective force on the tumor, which grows as an invasive mass with fingering margins, dominated by a few clones with aggressive traits. In contrast, mild microenvironment conditions (e.g., normoxia, homogeneous matrix) allow clones with similar aggressive traits to coexist with less aggressive phenotypes in a heterogeneous tumor mass with smooth, noninvasive margins. Thus, the genetic make-up of a cancer cell may realize its invasive potential through a clonal evolution process driven by definable microenvironmental selective forces. Our mathematical model provides a theoretical/experimental framework to quantitatively characterize this selective pressure for invasion and test ways to eliminate it.",
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    Anderson, ARA, Weaver, AM, Cummings, PT & Quaranta, V 2006, 'Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment', Cell, vol. 127, no. 5, pp. 905-915. https://doi.org/10.1016/j.cell.2006.09.042

    Tumor Morphology and Phenotypic Evolution Driven by Selective Pressure from the Microenvironment. / Anderson, Alexander R.A.; Weaver, Alissa M.; Cummings, Peter T.; Quaranta, Vito.

    In: Cell, Vol. 127, No. 5, 2006, p. 905-915.

    Research output: Contribution to journalArticle

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    AU - Weaver, Alissa M.

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