Tumour-stromal interactions: phenotypic and genetic alterations in mammary stroma: implications for tumour progression

Seth Schor, Ana M. Schor

    Research output: Contribution to journalArticlepeer-review

    79 Citations (Scopus)

    Abstract

    In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer.
    Original languageEnglish
    Article number373
    Number of pages7
    JournalBreast Cancer Research
    Volume3
    Issue number6
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Cancer progression
    • Cell motility
    • Epithelial-stromal interactions
    • Fibronectin

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