Abstract
In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer.
Original language | English |
---|---|
Article number | 373 |
Number of pages | 7 |
Journal | Breast Cancer Research |
Volume | 3 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Cancer progression
- Cell motility
- Epithelial-stromal interactions
- Fibronectin