Tumour-stromal interactions: phenotypic and genetic alterations in mammary stroma: implications for tumour progression

TY - JOUR

T1 - Tumour-stromal interactions

T2 - phenotypic and genetic alterations in mammary stroma: implications for tumour progression

AU - Schor, Seth

AU - Schor, Ana M.

N1 - dc.publisher: BioMed Central Ltd Summarises our research dealing with the significant role played by the extracellular matrix in driving cancer progression. Makes the important point that the precise action of well characterised soluble regulatory molecules (such as cytokines) is not invariant, but modulated by matrix remodelling which characterise tumour development.

PY - 2001

Y1 - 2001

N2 - In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer.

AB - In addition to the well documented role of cytokines in mediating tissue-level interactions, it is now clear that matrix macromolecules fulfil a complementary regulatory function. Data highlighted in the present review extend the repertoire of matrix signalling mechanisms, (1) introducing the concept of 'matrikines', these defined as proteinase-generated fragments of matrix macromolecules that display cryptic bioactivities not manifested by the native, full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform of fibronectin, which displays bioactivities cryptic in all previously identified fibronectin isoforms. These observations are discussed in the context of the contribution of a 'foetal-like' stroma to the progression of breast cancer.

KW - Cancer progression

KW - Cell motility

KW - Epithelial-stromal interactions

KW - Fibronectin

U2 - 10.1186/bcr325

DO - 10.1186/bcr325

M3 - Article

SN - 1465-5411

VL - 3

JO - Breast Cancer Research

JF - Breast Cancer Research

IS - 6

M1 - 373

ER -