Tumour suppression by p53: a role for the DNA damage response?

David W. Meek

    Research output: Contribution to journalReview article

    437 Citations (Scopus)

    Abstract

    Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.

    Original languageEnglish
    Pages (from-to)714-723
    Number of pages10
    JournalNature Reviews Cancer
    Volume9
    Issue number10
    DOIs
    Publication statusPublished - Oct 2009

    Keywords

    • UBIQUITIN LIGASE ACTIVITY
    • EARLY EMBRYONIC LETHALITY
    • APOPTOTIC TARGET GENES
    • IN-VIVO
    • P53-DEPENDENT APOPTOSIS
    • ATAXIA-TELANGIECTASIA
    • IONIZING-RADIATION
    • ACTIVATES P53
    • CELLULAR SENESCENCE
    • HUMAN CANCER

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