Tumour suppression by p53: a role for the DNA damage response?

David W. Meek

doi:10.1038/nrc2716

Tumour suppression by p53: a role for the DNA damage response?

David W. Meek

Research output: Contribution to journal › Review article › peer-review

544 Citations (Scopus)

Abstract

Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.

Original language	English
Pages (from-to)	714-723
Number of pages	10
Journal	Nature Reviews Cancer
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nrc2716
Publication status	Published - Oct 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

UBIQUITIN LIGASE ACTIVITY
EARLY EMBRYONIC LETHALITY
APOPTOTIC TARGET GENES
IN-VIVO
P53-DEPENDENT APOPTOSIS
ATAXIA-TELANGIECTASIA
IONIZING-RADIATION
ACTIVATES P53
CELLULAR SENESCENCE
HUMAN CANCER

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title = "Tumour suppression by p53: a role for the DNA damage response?",

abstract = "Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.",

keywords = "UBIQUITIN LIGASE ACTIVITY, EARLY EMBRYONIC LETHALITY, APOPTOTIC TARGET GENES, IN-VIVO, P53-DEPENDENT APOPTOSIS, ATAXIA-TELANGIECTASIA, IONIZING-RADIATION, ACTIVATES P53, CELLULAR SENESCENCE, HUMAN CANCER",

author = "Meek, \{David W.\}",

year = "2009",

month = oct,

doi = "10.1038/nrc2716",

language = "English",

volume = "9",

pages = "714--723",

journal = "Nature Reviews Cancer",

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publisher = "Nature Research",

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T1 - Tumour suppression by p53

T2 - a role for the DNA damage response?

AU - Meek, David W.

PY - 2009/10

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N2 - Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.

AB - Loss of p53 function occurs during the development of most, if not all, tumour types. This paves the way for genomic instability, tumour-associated changes in metabolism, insensitivity to apoptotic signals, invasiveness and motility. However, the nature of the causal link between early tumorigenic events and the induction of the p53-mediated checkpoints that constitute a barrier to tumour progression remains uncertain. This Review considers the role of the DNA damage response, which is activated during the early stages of tumour development, in mobilizing the tumour suppression function of p53. The relationship between these events and oncogene-induced p53 activation through the ARF pathway is also discussed.

KW - UBIQUITIN LIGASE ACTIVITY

KW - EARLY EMBRYONIC LETHALITY

KW - APOPTOTIC TARGET GENES

KW - IN-VIVO

KW - P53-DEPENDENT APOPTOSIS

KW - ATAXIA-TELANGIECTASIA

KW - IONIZING-RADIATION

KW - ACTIVATES P53

KW - CELLULAR SENESCENCE

KW - HUMAN CANCER

U2 - 10.1038/nrc2716

DO - 10.1038/nrc2716

M3 - Review article

C2 - 19730431

SN - 1474-175X

VL - 9

SP - 714

EP - 723

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 10

ER -

Tumour suppression by p53: a role for the DNA damage response?

Abstract

UN SDGs

Keywords

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