Abstract
By combining genome-wide association data from 8,130 individuals with type 2 diabetes (T2D) and 38,987 controls of European descent and following up previously unidentified meta-analysis signals in a further 34,412 cases and 59,925 controls, we identified 12 new T2D association signals with combined P < 5 x 10(-8). These include a second independent signal at the KCNQ1 locus; the first report, to our knowledge, of an X-chromosomal association (near DUSP9); and a further instance of overlap between loci implicated in monogenic and multifactorial forms of diabetes (at HNF1A). The identified loci affect both beta-cell function and insulin action, and, overall, T2D association signals show evidence of enrichment for genes involved in cell cycle regulation. We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits.
Original language | English |
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Pages (from-to) | 579-U155 |
Number of pages | 13 |
Journal | Nature Genetics |
Volume | 42 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2010 |
Keywords
- GENOME-WIDE ASSOCIATION
- C-REACTIVE PROTEIN
- FASTING PLASMA-GLUCOSE
- QT INTERVAL DURATION
- INSULIN-RESISTANCE
- COMMON VARIANTS
- COMPLEX DISEASES
- GENE-EXPRESSION
- HNF1-ALPHA GENE
- CROHNS-DISEASE