Two high-resolution structures of the human E3 ubiquitin ligase Siah1

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• Finished

  A Translational Engine for Biomedical Discoveries (Strategic Grant)

  Fairlamb, A. (Investigator) & Gilbert, I. (Investigator)

  1/01/13 → 30/09/15

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Proteolysis 73%
  • Visceral Leishmaniasis 67%
  • Trypanosoma Brucei 61%
  • Ubiquitin-Conjugating Enzyme 60%

• State-of-the-Art Facilities for Structural Biology at the University of Dundee

  Hunter, B. (Investigator), Lilley, D. (Investigator), Owen-Hughes, T. (Investigator), Wyatt, P. (Investigator) & van Aalten, D. (Investigator)

  1/03/12 → 28/02/17

  Project: Research

  • Proteolysis Targeting chimera (PROTAC) 100%
  • Crystal Structure 74%
  • Enzyme 66%
  • Proteolysis 63%
  • Degrader 57%

• Aref#d: 19401. Structure, specificity and mechanism of biosynthetic enzymes in trypanosomatids and inhibitor discovery of essential microbial functions (Programme Grant)

  Hunter, B. (Investigator)

  1/11/07 → 31/12/13

  Project: Research

  • Enzyme 100%
  • Crystal Structure 92%
  • Trypanosoma Brucei 69%
  • Active Sites 67%
  • Active Site 61%