Ultra high speed observations of cavitation derived microjetting phenomena

P. A. Prentice, J. M. Burns, D. McLean, A. Cuschieri, W. Sibbett, P. A. Campbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ultrasound mediated molecular delivery (sonoporation) is a highly attractive route for cancer- and gene-therapy. This has been demonstrated, both in vitro and in animal trials, to achieve a number of critical bioeffects such as apoptosis, lysis and tumour regression. Moreover, it is now accepted that the clinical potential is enhanced when ultrasound contrast agent (UCA) microbubbles are present during insonation. However, the fundamental mechanism of interaction between cell and microbubble during US exposure remains elusive and this hampers attempts to optimise the approach. In addressing this deficiency in our understanding, we designed and constructed a unique apparatus that can optically guide an individual UCA microbubble to a predefined displacement relative to a planar substrate. In parallel with this, we undertook direct observations, via high speed imaging at MHz frame rates. We demonstrate how this approach has allowed us to observe a dynamic microscopic interaction during insonation, that may give rise to membrane permeabilization in biological cells.

Original languageEnglish
Title of host publication2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Place of PublicationPiscataway
PublisherIEEE
Pages160-161
Number of pages2
ISBN (Print)0780387112, 9780780387119
DOIs
Publication statusPublished - 2005
Event2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology - Oahu, HI, United States
Duration: 12 May 200515 May 2005

Conference

Conference2005 3rd IEEE/EMBS Special Topic Conference on Microtechnology in Medicine and Biology
Country/TerritoryUnited States
CityOahu, HI
Period12/05/0515/05/05

Keywords

  • Cancer and gene therapy
  • Drug and molecular delivery
  • Microjetting
  • Optical trapping
  • Ultra high speed imaging

ASJC Scopus subject areas

  • General Engineering

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