Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Dana Gourevich, Bjoern Gerold, Fabian Arditti, Doudou Xu, Dun Liu, Alex Volovick, Lijun Wang, Yoav Medan, Jallal Gnaim, Paul Prentice, Sandy Cochran, Andreas Melzer

    Research output: Chapter in Book/Report/Conference proceedingChapter

    12 Citations (Scopus)

    Abstract

    Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).
    Original languageEnglish
    Title of host publicationNano-biotechnology for biomedical and diagnostic research
    EditorsEran Zahavy, Arie Ordentlich, Shmuel Yitzhaki, Avigdor Shafferman
    PublisherSpringer
    Pages135-44
    Number of pages10
    Volume733
    ISBN (Electronic)9789400725553
    ISBN (Print)9789400725546
    DOIs
    Publication statusPublished - 2012

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume733

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