Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Dana Gourevich; Bjoern Gerold; Fabian Arditti; Doudou Xu; Dun Liu; Alex Volovick; Lijun Wang; Yoav Medan; Jallal Gnaim; Paul Prentice; Sandy Cochran; Andreas Melzer

doi:10.1007/978-94-007-2555-3_13

Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Dana Gourevich
, Bjoern Gerold
, Fabian Arditti
, Doudou Xu
, Dun Liu
, Alex Volovick
, Lijun Wang
, Yoav Medan
, Jallal Gnaim
, Paul Prentice
, Sandy Cochran
, Andreas Melzer

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).

Original language	English
Title of host publication	Nano-biotechnology for biomedical and diagnostic research
Editors	Eran Zahavy, Arie Ordentlich, Shmuel Yitzhaki, Avigdor Shafferman
Publisher	Springer
Pages	135-44
Number of pages	10
Volume	733
ISBN (Electronic)	9789400725553
ISBN (Print)	9789400725546
DOIs	https://doi.org/10.1007/978-94-007-2555-3_13
Publication status	Published - 2012

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	733

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1007/978-94-007-2555-3_13

Cite this

Gourevich, D., Gerold, B., Arditti, F., Xu, D., Liu, D., Volovick, A., Wang, L., Medan, Y., Gnaim, J., Prentice, P., Cochran, S., & Melzer, A. (2012). Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. In E. Zahavy, A. Ordentlich, S. Yitzhaki, & A. Shafferman (Eds.), Nano-biotechnology for biomedical and diagnostic research (Vol. 733, pp. 135-44). (Advances in Experimental Medicine and Biology; Vol. 733). Springer . https://doi.org/10.1007/978-94-007-2555-3_13

Gourevich, Dana ; Gerold, Bjoern ; Arditti, Fabian et al. / Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. Nano-biotechnology for biomedical and diagnostic research. editor / Eran Zahavy ; Arie Ordentlich ; Shmuel Yitzhaki ; Avigdor Shafferman. Vol. 733 Springer , 2012. pp. 135-44 (Advances in Experimental Medicine and Biology).

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title = "Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration",

abstract = "Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).",

author = "Dana Gourevich and Bjoern Gerold and Fabian Arditti and Doudou Xu and Dun Liu and Alex Volovick and Lijun Wang and Yoav Medan and Jallal Gnaim and Paul Prentice and Sandy Cochran and Andreas Melzer",

year = "2012",

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language = "English",

isbn = "9789400725546",

volume = "733",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer ",

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editor = "Eran Zahavy and Arie Ordentlich and Shmuel Yitzhaki and Avigdor Shafferman",

booktitle = "Nano-biotechnology for biomedical and diagnostic research",

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Gourevich, D, Gerold, B, Arditti, F, Xu, D, Liu, D, Volovick, A, Wang, L, Medan, Y, Gnaim, J, Prentice, P, Cochran, S & Melzer, A 2012, Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. in E Zahavy, A Ordentlich, S Yitzhaki & A Shafferman (eds), Nano-biotechnology for biomedical and diagnostic research. vol. 733, Advances in Experimental Medicine and Biology, vol. 733, Springer , pp. 135-44. https://doi.org/10.1007/978-94-007-2555-3_13

Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. / Gourevich, Dana; Gerold, Bjoern; Arditti, Fabian et al.
Nano-biotechnology for biomedical and diagnostic research. ed. / Eran Zahavy; Arie Ordentlich; Shmuel Yitzhaki; Avigdor Shafferman. Vol. 733 Springer , 2012. p. 135-44 (Advances in Experimental Medicine and Biology; Vol. 733).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

TY - CHAP

T1 - Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

AU - Gourevich, Dana

AU - Gerold, Bjoern

AU - Arditti, Fabian

AU - Xu, Doudou

AU - Liu, Dun

AU - Volovick, Alex

AU - Wang, Lijun

AU - Medan, Yoav

AU - Gnaim, Jallal

AU - Prentice, Paul

AU - Cochran, Sandy

AU - Melzer, Andreas

PY - 2012

Y1 - 2012

N2 - Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).

AB - Recently, ultrasonic drug release has been a focus of many research groups for stimuli responsive drug release. It has been demonstrated that a focused ultrasound (FUS) beam rapidly increases the temperature at the focused tissue area. One potential mechanism of drug targeting is to utilize the induced heat to release or increase penetration of chemotherapy to cancer cells. The efficiency of targeted drug delivery may increase by using FUS beam in conjugation with nano--encapsulated drug carriers.The aim of this study is to investigate the effect of heat and ultrasound on the cellular uptake and therapeutic efficacy of an anticancer drug using Magnetic Resonance Imaging guided Focused Ultrasound (MRgFUS).

U2 - 10.1007/978-94-007-2555-3_13

DO - 10.1007/978-94-007-2555-3_13

M3 - Chapter

C2 - 22101719

SN - 9789400725546

VL - 733

T3 - Advances in Experimental Medicine and Biology

SP - 135

EP - 144

BT - Nano-biotechnology for biomedical and diagnostic research

A2 - Zahavy, Eran

A2 - Ordentlich, Arie

A2 - Yitzhaki, Shmuel

A2 - Shafferman, Avigdor

PB - Springer

ER -

Gourevich D, Gerold B, Arditti F, Xu D, Liu D, Volovick A et al. Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration. In Zahavy E, Ordentlich A, Yitzhaki S, Shafferman A, editors, Nano-biotechnology for biomedical and diagnostic research. Vol. 733. Springer . 2012. p. 135-44. (Advances in Experimental Medicine and Biology). doi: 10.1007/978-94-007-2555-3_13

Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration

Abstract

Publication series

UN SDGs

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