Ultrasound assisted particle and cell manipulation on-chip

Helen Mulvana, Sandy Cochran, Martyn Hill

    Research output: Contribution to journalArticle

    44 Citations (Scopus)

    Abstract

    Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.
    Original languageEnglish
    Pages (from-to)1600-1610
    Number of pages11
    JournalAdvanced Drug Delivery Reviews
    Volume65
    Issue number11-12
    DOIs
    Publication statusPublished - 15 Nov 2013

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