TY - JOUR
T1 - Ultrasound assisted particle and cell manipulation on-chip
AU - Mulvana, Helen
AU - Cochran, Sandy
AU - Hill, Martyn
PY - 2013/11/15
Y1 - 2013/11/15
N2 - Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.
AB - Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.
UR - http://www.scopus.com/inward/record.url?scp=84887617989&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2013.07.016
DO - 10.1016/j.addr.2013.07.016
M3 - Article
C2 - 23906935
AN - SCOPUS:84887617989
SN - 0169-409X
VL - 65
SP - 1600
EP - 1610
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
IS - 11-12
ER -