Ultrasound assisted particle and cell manipulation on-chip

TY - JOUR

T1 - Ultrasound assisted particle and cell manipulation on-chip

AU - Mulvana, Helen

AU - Cochran, Sandy

AU - Hill, Martyn

PY - 2013/11/15

Y1 - 2013/11/15

N2 - Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.

AB - Ultrasonic fields are able to exert forces on cells and other micron-scale particles, including microbubbles. The technology is compatible with existing lab-on-chip techniques and is complementary to many alternative manipulation approaches due to its ability to handle many cells simultaneously over extended length scales. This paper provides an overview of the physical principles underlying ultrasonic manipulation, discusses the biological effects relevant to its use with cells, and describes emerging applications that are of interest in the field of drug development and delivery on-chip.

UR - https://www.scopus.com/pages/publications/84887617989

U2 - 10.1016/j.addr.2013.07.016

DO - 10.1016/j.addr.2013.07.016

M3 - Article

C2 - 23906935

AN - SCOPUS:84887617989

SN - 0169-409X

VL - 65

SP - 1600

EP - 1610

JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

IS - 11-12

ER -