Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound: A Porcine Study

Yongqiang Qiu, Yaocai Huang, Zhiqiang Zhang, Benjamin F. Cox, Rong Liu, Jiehan Hong, Peitian Mu, Holly S. Lay, Gerard Cummins, Marc P. Y. Desmulliez, Eddie Clutton, Hairong Zheng, Weibao Qiu (Lead / Corresponding author), Sandy Cochran

Research output: Contribution to journalArticle

Abstract

Wireless capsule endoscopy has been used for the clinical examination of the gastrointestinal (GI) tract for two decades. However, most commercially available devices only utilise optical imaging to examine the GI wall surface. Using this sensing modality, pathology within the GI wall cannot be detected. Micro-ultrasound (μUS) using high-frequency (>20 MHz) ultrasound can provide a means of transmural or cross-sectional image of the GI tract. Depth of imaging is approximately 10 mm with a resolution of between 40–120 μm that is sufficient to differentiate between subsurface histologic layers of the various regions of the GI tract. Ultrasound capsule endoscopy (USCE) uses a capsule equipped with μUS transducers that are capable of imaging below the GI wall surface, offering thereby a complementary sensing technique to optical imaging capsule endoscopy. In this work, a USCE device integrated with a ∼30 MHz ultrasonic transducer was developed to capture a full 360° image of the lumen. The performance of the device was initially evaluated using a wire phantom, indicating an axial resolution of 69.0 μm and lateral resolution of 262.5 μm. Later, in vivo imaging performance was characterised in the oesophagus and small intestine of anaesthetized pigs. The reconstructed images demonstrate clear layer differentiation of the lumen wall. The tissue thicknesses measured from the B-scan images show good agreement with ex vivo images from the literature. The high-resolution ultrasound images in the in vivo porcine model achieved with this device is an encouraging preliminary step in the translation of these devices toward future clinical use.

Original languageEnglish
Number of pages9
JournalUltrasound in Medicine and Biology
Early online date3 Jan 2020
DOIs
Publication statusE-pub ahead of print - 3 Jan 2020

Fingerprint

Capsule Endoscopy
capsules
Swine
Equipment and Supplies
scanning
Gastrointestinal Tract
Optical Imaging
Transducers
lumens
transducers
esophagus
intestines
swine
Ultrasonics
Esophagus
Small Intestine
pathology
Capsules
Pathology
ultrasonics

Keywords

  • Capsule endoscopy
  • High-frequency ultrasound
  • In vivo porcine animal study
  • Micro-ultrasound capsule endoscopy

Cite this

Qiu, Yongqiang ; Huang, Yaocai ; Zhang, Zhiqiang ; Cox, Benjamin F. ; Liu, Rong ; Hong, Jiehan ; Mu, Peitian ; Lay, Holly S. ; Cummins, Gerard ; Desmulliez, Marc P. Y. ; Clutton, Eddie ; Zheng, Hairong ; Qiu, Weibao ; Cochran, Sandy. / Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound : A Porcine Study. In: Ultrasound in Medicine and Biology. 2020.
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abstract = "Wireless capsule endoscopy has been used for the clinical examination of the gastrointestinal (GI) tract for two decades. However, most commercially available devices only utilise optical imaging to examine the GI wall surface. Using this sensing modality, pathology within the GI wall cannot be detected. Micro-ultrasound (μUS) using high-frequency (>20 MHz) ultrasound can provide a means of transmural or cross-sectional image of the GI tract. Depth of imaging is approximately 10 mm with a resolution of between 40–120 μm that is sufficient to differentiate between subsurface histologic layers of the various regions of the GI tract. Ultrasound capsule endoscopy (USCE) uses a capsule equipped with μUS transducers that are capable of imaging below the GI wall surface, offering thereby a complementary sensing technique to optical imaging capsule endoscopy. In this work, a USCE device integrated with a ∼30 MHz ultrasonic transducer was developed to capture a full 360° image of the lumen. The performance of the device was initially evaluated using a wire phantom, indicating an axial resolution of 69.0 μm and lateral resolution of 262.5 μm. Later, in vivo imaging performance was characterised in the oesophagus and small intestine of anaesthetized pigs. The reconstructed images demonstrate clear layer differentiation of the lumen wall. The tissue thicknesses measured from the B-scan images show good agreement with ex vivo images from the literature. The high-resolution ultrasound images in the in vivo porcine model achieved with this device is an encouraging preliminary step in the translation of these devices toward future clinical use.",
keywords = "Capsule endoscopy, High-frequency ultrasound, In vivo porcine animal study, Micro-ultrasound capsule endoscopy",
author = "Yongqiang Qiu and Yaocai Huang and Zhiqiang Zhang and Cox, {Benjamin F.} and Rong Liu and Jiehan Hong and Peitian Mu and Lay, {Holly S.} and Gerard Cummins and Desmulliez, {Marc P. Y.} and Eddie Clutton and Hairong Zheng and Weibao Qiu and Sandy Cochran",
note = "This work was supported by UK Engineering and Physical Sciences Research Council grant entitled Sonopill (EP/K034537/1), National Science Foundation Grants of China (11874382, 11804357, 11534013, 11574342 and 81927808), Shenzhen Research grant nos. (GJHZ20180420180920529, JCYJ20170817171836611, JCYJ20170413164936017 and ZDSYS201802061806314), Natural Science Foundation of Guangdong Province (2015 A030306018, 2014 B030301013 and 2014 A030312006), Shenzhen Double Chain Project [2018]256, CAS research projects (QYZDB-SSW-JSC018 and YJKYYQ20170065) and Guangdong Special Support Program.",
year = "2020",
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Qiu, Y, Huang, Y, Zhang, Z, Cox, BF, Liu, R, Hong, J, Mu, P, Lay, HS, Cummins, G, Desmulliez, MPY, Clutton, E, Zheng, H, Qiu, W & Cochran, S 2020, 'Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound: A Porcine Study', Ultrasound in Medicine and Biology. https://doi.org/10.1016/j.ultrasmedbio.2019.12.003

Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound : A Porcine Study. / Qiu, Yongqiang; Huang, Yaocai; Zhang, Zhiqiang; Cox, Benjamin F.; Liu, Rong; Hong, Jiehan; Mu, Peitian; Lay, Holly S.; Cummins, Gerard; Desmulliez, Marc P. Y.; Clutton, Eddie; Zheng, Hairong; Qiu, Weibao (Lead / Corresponding author); Cochran, Sandy.

In: Ultrasound in Medicine and Biology, 03.01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ultrasound Capsule Endoscopy With a Mechanically Scanning Micro-ultrasound

T2 - A Porcine Study

AU - Qiu, Yongqiang

AU - Huang, Yaocai

AU - Zhang, Zhiqiang

AU - Cox, Benjamin F.

AU - Liu, Rong

AU - Hong, Jiehan

AU - Mu, Peitian

AU - Lay, Holly S.

AU - Cummins, Gerard

AU - Desmulliez, Marc P. Y.

AU - Clutton, Eddie

AU - Zheng, Hairong

AU - Qiu, Weibao

AU - Cochran, Sandy

N1 - This work was supported by UK Engineering and Physical Sciences Research Council grant entitled Sonopill (EP/K034537/1), National Science Foundation Grants of China (11874382, 11804357, 11534013, 11574342 and 81927808), Shenzhen Research grant nos. (GJHZ20180420180920529, JCYJ20170817171836611, JCYJ20170413164936017 and ZDSYS201802061806314), Natural Science Foundation of Guangdong Province (2015 A030306018, 2014 B030301013 and 2014 A030312006), Shenzhen Double Chain Project [2018]256, CAS research projects (QYZDB-SSW-JSC018 and YJKYYQ20170065) and Guangdong Special Support Program.

PY - 2020/1/3

Y1 - 2020/1/3

N2 - Wireless capsule endoscopy has been used for the clinical examination of the gastrointestinal (GI) tract for two decades. However, most commercially available devices only utilise optical imaging to examine the GI wall surface. Using this sensing modality, pathology within the GI wall cannot be detected. Micro-ultrasound (μUS) using high-frequency (>20 MHz) ultrasound can provide a means of transmural or cross-sectional image of the GI tract. Depth of imaging is approximately 10 mm with a resolution of between 40–120 μm that is sufficient to differentiate between subsurface histologic layers of the various regions of the GI tract. Ultrasound capsule endoscopy (USCE) uses a capsule equipped with μUS transducers that are capable of imaging below the GI wall surface, offering thereby a complementary sensing technique to optical imaging capsule endoscopy. In this work, a USCE device integrated with a ∼30 MHz ultrasonic transducer was developed to capture a full 360° image of the lumen. The performance of the device was initially evaluated using a wire phantom, indicating an axial resolution of 69.0 μm and lateral resolution of 262.5 μm. Later, in vivo imaging performance was characterised in the oesophagus and small intestine of anaesthetized pigs. The reconstructed images demonstrate clear layer differentiation of the lumen wall. The tissue thicknesses measured from the B-scan images show good agreement with ex vivo images from the literature. The high-resolution ultrasound images in the in vivo porcine model achieved with this device is an encouraging preliminary step in the translation of these devices toward future clinical use.

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KW - Capsule endoscopy

KW - High-frequency ultrasound

KW - In vivo porcine animal study

KW - Micro-ultrasound capsule endoscopy

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