Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

B. F. Cox, F. Stewart, Z. Huang, I. S. Nathke, S. Cochran

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)
121 Downloads (Pure)

Abstract

The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.

Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium (IUS)
PublisherIEEE Computer Society
Pages1-4
Number of pages4
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
Publication statusPublished - 3 Nov 2016
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: 18 Sep 201621 Sep 2016

Conference

Conference2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period18/09/1621/09/16

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Keywords

  • Focused Ultrasound
  • Gastrointetinal tract
  • Gut Barrier
  • Quantum Dot
  • Tissue Marking

Cite this

Cox, B. F., Stewart, F., Huang, Z., Nathke, I. S., & Cochran, S. (2016). Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material. In 2016 IEEE International Ultrasonics Symposium (IUS) (Vol. 2016-November, pp. 1-4). [7728782] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728782