Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

B. F. Cox; F. Stewart; Z. Huang; I. S. Nathke; S. Cochran

doi:10.1109/ULTSYM.2016.7728782

Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

B. F. Cox, F. Stewart, Z. Huang, I. S. Nathke, S. Cochran

School of Life Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Citations (Scopus)

283 Downloads (Pure)

Abstract

The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.

Original language	English
Title of host publication	2016 IEEE International Ultrasonics Symposium (IUS)
Publisher	IEEE Computer Society
Pages	1-4
Number of pages	4
Volume	2016-November
ISBN (Electronic)	9781467398978
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728782
Publication status	Published - 3 Nov 2016
Event	2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France Duration: 18 Sept 2016 → 21 Sept 2016

Conference

Conference	2016 IEEE International Ultrasonics Symposium, IUS 2016
Country/Territory	France
City	Tours
Period	18/09/16 → 21/09/16

Keywords

Focused Ultrasound
Gastrointetinal tract
Gut Barrier
Quantum Dot
Tissue Marking

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2016.7728782

Author accepted manuscript
© 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Accepted author manuscript, 619 KB

Cite this

@inproceedings{b30257d354e149ebb94fc435308e9536,

title = "Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material",

abstract = "The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.",

keywords = "Focused Ultrasound, Gastrointetinal tract, Gut Barrier, Quantum Dot, Tissue Marking",

author = "Cox, {B. F.} and F. Stewart and Z. Huang and Nathke, {I. S.} and S. Cochran",

note = " UK EPSRC for funding the work under the Sonopill programme (EP/K034537).; 2016 IEEE International Ultrasonics Symposium, IUS 2016 ; Conference date: 18-09-2016 Through 21-09-2016",

year = "2016",

month = nov,

day = "3",

doi = "10.1109/ULTSYM.2016.7728782",

language = "English",

volume = "2016-November",

pages = "1--4",

booktitle = "2016 IEEE International Ultrasonics Symposium (IUS)",

publisher = "IEEE Computer Society",

}

Cox, BF, Stewart, F, Huang, Z, Nathke, IS & Cochran, S 2016, Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material. in 2016 IEEE International Ultrasonics Symposium (IUS). vol. 2016-November, 7728782, IEEE Computer Society, pp. 1-4, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 18/09/16. https://doi.org/10.1109/ULTSYM.2016.7728782

TY - GEN

T1 - Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

AU - Cox, B. F.

AU - Stewart, F.

AU - Huang, Z.

AU - Nathke, I. S.

AU - Cochran, S.

N1 - UK EPSRC for funding the work under the Sonopill programme (EP/K034537).

PY - 2016/11/3

Y1 - 2016/11/3

N2 - The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.

AB - The epithelial lining of the gastrointestinal (GI) mucosal layer is an effective barrier to the contents of the gut lumen. Selective channels and tight junctions prevent contamination of the sterile internal environment of the body. Conversely, the gut barrier also prevents desired agents from entering the GI tissue. This hinders marking of tissue for further clinical follow-up. Focused ultrasound (US) may provide a potential means of overcoming the gut barrier and allowing penetration of material beyond it which was explored in a series of tests. Experiments were carried out on 14 individual postmortem-obtained murine small bowel samples for a total of 23 sonication/control paired tests. A favourable result of 80% indicated that focused US can pass a nanoscale fluorescent agent through the gut barrier. Further work is required to elucidate where the agent resides, intercellular or intracellular, post-sonication.

KW - Focused Ultrasound

KW - Gastrointetinal tract

KW - Gut Barrier

KW - Quantum Dot

KW - Tissue Marking

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U2 - 10.1109/ULTSYM.2016.7728782

DO - 10.1109/ULTSYM.2016.7728782

M3 - Conference contribution

AN - SCOPUS:84996565361

VL - 2016-November

SP - 1

EP - 4

BT - 2016 IEEE International Ultrasonics Symposium (IUS)

PB - IEEE Computer Society

T2 - 2016 IEEE International Ultrasonics Symposium, IUS 2016

Y2 - 18 September 2016 through 21 September 2016

ER -

Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this

Ultrasound facilitated marking of gastrointestinal tissue with fluorescent material

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Projects

Sonopill: Minimally Invasive Gastrointestinal Diagnosis and Therapy (Joint with University of Glasgow & Heriot Watt University)

Cite this