Ultrasound-mediated targeted drug delivery generated by multifocal beam patterns: an in vitro study

Dana Gourevich, Yoni Hertzberg, Alexander Volovick (Lead / Corresponding author), Yaron Shafran, Gil Navon, Sandy Cochran, Andreas Melzer

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)


    Ultrasound-mediated targeted drug delivery has been a subject for a dedicated research activity for several decades. Nevertheless, in vitro studies in this field of research are characterized by their inconsistencies. To improve the repeatability of such experiments, a novel approach of multifocal spot generation was investigated. A multifocal pattern of 16 spots was utilized using an iterative Gerchberg-Saxton algorithm. The pattern was applied to insonate a 96-well Petri dish plate using a clinically available planar-phased array transducer with approximately 1000 elements with a central frequency of 0.55 MHz. The pattern was acoustically characterized and applied to a monolayer of human breast cancer cell line in the 96-well plate. With the help of ultrasonic contrast agents, the intracellular drug uptake was increased by an average factor of 3.5 compared with the control group. (E-mail: a.volovyk@dundee.ac.uk) (C) 2013 World Federation for Ultrasound in Medicine & Biology.

    Original languageEnglish
    Pages (from-to)507-514
    Number of pages8
    JournalUltrasound in Medicine and Biology
    Issue number3
    Publication statusPublished - 2013


    • Focused ultrasound
    • ASSAY
    • CELLS
    • Multifocus beam patterns
    • Microbubbles
    • Cancer cell lines
    • Targeted drug delivery


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