Ultrasound-mediated targeted drug delivery with a novel cyclodextrin-based drug carrier by mechanical and thermal mechanisms

Dana Gourevich (Lead / Corresponding author), Osnat Dogadkin, Alexander Volovick, Lijun Wang, Jallal Gnaim, Sandy Cochran, Andreas Melzer

    Research output: Contribution to journalArticlepeer-review

    40 Citations (Scopus)

    Abstract

    Various mechanisms for ultrasound-mediated targeted drug delivery have been investigated in the past several decades. Cyclodextrins are already known for their ability to encapsulate various drugs in their lipophilic cavity; this paper reports evaluation of the potential of a cyclodextrin-based nanocarrier as a drug delivery vehicle, using cell monolayers in vitro in conjunction with ultrasound as the release mechanism. The application of ultrasound to the cell monolayers results in both thermal and mechanical effects; a current challenge is to differentiate between these effects. In this study, the cell uptake routes of doxorubicin encapsulated in the cyclodextrin-based carrier were investigated, examining individually the thermal and the mechanical effects of focused ultrasound for drug release. Exploiting mechanical effects, the uptake of encapsulated doxorubicin into cancer cells was increased by a factor of up to 5.5 when ultrasound was applied. Thermal application of FUS increased the cellular uptake of encapsulated doxorubicin by a factor of up to 9.6. Hyperthermia without focused ultrasound resulted in an increase by a factor of up to 5.7.
    Original languageEnglish
    Pages (from-to)316-324
    Number of pages9
    JournalJournal of Controlled Release: Official Journal of the Controlled Release Society, and of the Japan Society of Drug Delivery System
    Volume170
    Issue number3
    DOIs
    Publication statusPublished - 28 Sep 2013

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