Ultrasound standing wave device for particle manipulation

Yongqiang Qiu, Christine Demore, Sandy Cochran

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Abstract

    Using ultrasonic standing waves for noncontact manipulation of microparticles or cells has raised many possible applications in life sciences and medicine. This paper introduces the basic concept and methods of applying ultrasound to manipulate the microparticles in fluids, and also gives two practical examples of trapping and manipulating microparticles with ultrasound standing waves. The design, simulation, fabrication and testing of these two resonant-mode ultrasonic manipulation devices are presented, and some practical issues are discussed, such as temperature changes and streaming. The first device uses a bespoke high frequency (up to 25 MHz) lithium niobate transducer coupled to a fabricated precision reflector and spacers to form a multiple of half-wavelength ultrasound standing waves (30 µm) across a macroscale fluid chamber (2 × 5 mm2) in which the microparticles are distributed and trapped by ultrasonic radiation forces. The second device has a 12-element kerfless ultrasonic linear array (2.5 MHz) coupled to a disposable rectangular capillary to trap and manipulate microparticles along the capillary by controlling the active elements of the array. The experimental results of both devices with 10 µm polystyrene beads show correspondence with pressure distributions simulated with the finite element method and demonstrate the feasibility for potential applications in life sciences
    Original languageEnglish
    Title of host publicationMicroacoustics in marine and medical research
    EditorsSpiros Kotopoulis, Anthony Delalande, Olav Rune Godo, Michiel Postema
    Place of PublicationBergen
    PublisherKotopoulis
    Pages29-40
    Number of pages12
    ISBN (Print)9788230319451
    Publication statusPublished - 2012
    EventMicroacoustics in Marine and Medical Research workshop - Bergen, Norway
    Duration: 7 Dec 20118 Dec 2011

    Workshop

    WorkshopMicroacoustics in Marine and Medical Research workshop
    CountryNorway
    CityBergen
    Period7/12/118/12/11

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