Ultrasound-stimulated mutual interaction forces between optically configured micro-bubble pairs

Paul A. Prentice, Paul A. Campbell

    Research output: Contribution to journalConference article

    Abstract

    The mutual interaction between two oscillating encapsulated microbubbles was investigated using a novel optical trapping arrangement. This approach facilitated the development of an arbitrary, stable, initial spatial configuration for a two-bubble system. Critically, exercising optical control over such a binary bubble system meant that it could be isolated from the resident population of microbubbles during exposure to ultrasound. This ensured that any early stage dynamical evolution of the system was dominated by the mutual interaction of the two bubbles in view, rather than any extraneous influence arising from 'crosstalk' with the rest of the bubble population. We observed, using high speed microphotography at 4×105 frames per second, that the action of secondary radiation forces leads to mutual bubble attraction. Phenomena such as coalescence and 'bounce' were observed. Estimates of the microbubble [Sonovue™] compressibility could also be made, and tally well with published values obtained for other shelled contrast agents.

    Original languageEnglish
    Pages (from-to)212-218
    Number of pages7
    JournalAIP Conference Proceedings
    Volume911
    DOIs
    Publication statusPublished - 2007
    Event6th International Symposium on Therapeutic Ultrasound - Oxford, United Kingdom
    Duration: 30 Aug 20072 Sep 2007

    Fingerprint

    bubbles
    interactions
    optical control
    crosstalk
    coalescing
    compressibility
    attraction
    trapping
    high speed
    radiation
    estimates
    configurations

    Keywords

    • Bjerknes forces
    • Microbubbles
    • Ultrasound

    Cite this

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    title = "Ultrasound-stimulated mutual interaction forces between optically configured micro-bubble pairs",
    abstract = "The mutual interaction between two oscillating encapsulated microbubbles was investigated using a novel optical trapping arrangement. This approach facilitated the development of an arbitrary, stable, initial spatial configuration for a two-bubble system. Critically, exercising optical control over such a binary bubble system meant that it could be isolated from the resident population of microbubbles during exposure to ultrasound. This ensured that any early stage dynamical evolution of the system was dominated by the mutual interaction of the two bubbles in view, rather than any extraneous influence arising from 'crosstalk' with the rest of the bubble population. We observed, using high speed microphotography at 4×105 frames per second, that the action of secondary radiation forces leads to mutual bubble attraction. Phenomena such as coalescence and 'bounce' were observed. Estimates of the microbubble [Sonovue™] compressibility could also be made, and tally well with published values obtained for other shelled contrast agents.",
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    }

    Ultrasound-stimulated mutual interaction forces between optically configured micro-bubble pairs. / Prentice, Paul A.; Campbell, Paul A.

    In: AIP Conference Proceedings, Vol. 911, 2007, p. 212-218.

    Research output: Contribution to journalConference article

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    AU - Prentice, Paul A.

    AU - Campbell, Paul A.

    PY - 2007

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    AB - The mutual interaction between two oscillating encapsulated microbubbles was investigated using a novel optical trapping arrangement. This approach facilitated the development of an arbitrary, stable, initial spatial configuration for a two-bubble system. Critically, exercising optical control over such a binary bubble system meant that it could be isolated from the resident population of microbubbles during exposure to ultrasound. This ensured that any early stage dynamical evolution of the system was dominated by the mutual interaction of the two bubbles in view, rather than any extraneous influence arising from 'crosstalk' with the rest of the bubble population. We observed, using high speed microphotography at 4×105 frames per second, that the action of secondary radiation forces leads to mutual bubble attraction. Phenomena such as coalescence and 'bounce' were observed. Estimates of the microbubble [Sonovue™] compressibility could also be made, and tally well with published values obtained for other shelled contrast agents.

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