TY - JOUR
T1 - Unconventional secretion of plant extracellular vesicles and their benefits to human health
T2 - A mini review
AU - Farley, Joshua T.
AU - Eldahshoury, Mahmoud K.
AU - de Marcos Lousa, Carine
N1 - Funding Information:
JF and ME are supported by a PhD scholarship from Leeds Beckett University.
Copyright:
© 2022 Farley, Eldahshoury and de Marcos Lousa.
PY - 2022/6/1
Y1 - 2022/6/1
N2 - Mechanisms devoted to the secretion of proteins via extracellular vesicles (EVs) have been found in mammals, yeasts, and plants. Since they transport a number of leader-less proteins to the plasma membrane or the extracellular space, EVs are considered part of Unconventional protein secretion (UPS) routes. UPS involving EVs are a relatively new field in plants. Aside from their role in plant physiology and immunity, plant extracts containing EVs have also been shown to be beneficial for human health. Therefore, exploring the use of plant EVs in biomedicine and their potential as drug delivery tools is an exciting avenue. Here we give a summary of the state of knowledge on plant EVs, their crosstalk with mammalian systems and potential research routes that could lead to practical applications in therapeutic drug delivery.
AB - Mechanisms devoted to the secretion of proteins via extracellular vesicles (EVs) have been found in mammals, yeasts, and plants. Since they transport a number of leader-less proteins to the plasma membrane or the extracellular space, EVs are considered part of Unconventional protein secretion (UPS) routes. UPS involving EVs are a relatively new field in plants. Aside from their role in plant physiology and immunity, plant extracts containing EVs have also been shown to be beneficial for human health. Therefore, exploring the use of plant EVs in biomedicine and their potential as drug delivery tools is an exciting avenue. Here we give a summary of the state of knowledge on plant EVs, their crosstalk with mammalian systems and potential research routes that could lead to practical applications in therapeutic drug delivery.
KW - biomedicine
KW - biopharming
KW - exosomes
KW - extracellular vesicles
KW - plant EVs
KW - unconventional protein secretion (UPS)
UR - http://www.scopus.com/inward/record.url?scp=85132804944&partnerID=8YFLogxK
U2 - 10.3389/fcell.2022.883841
DO - 10.3389/fcell.2022.883841
M3 - Review article
C2 - 35721490
AN - SCOPUS:85132804944
SN - 2296-634X
VL - 10
JO - Frontiers in Cell and Developmental Biology
JF - Frontiers in Cell and Developmental Biology
M1 - 883841
ER -
