Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

Andrew P. South; Edel A. O'Toole

doi:10.1016/j.det.2009.10.023

Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

Andrew P. South, Edel A. O'Toole

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa associated squamous cell carcinoma.

Original language	English
Pages (from-to)	171-+
Number of pages	9
Journal	Dermatologic Clinics
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.det.2009.10.023
Publication status	Published - Jan 2010

Keywords

Epidermolysis bullosa
Cancer
Metastasis
COL7A1
Type VII collagen
VII COLLAGEN EXPRESSION
XERODERMA-PIGMENTOSUM PATIENTS
BASEMENT-MEMBRANE
MATRIX METALLOPROTEINASES
ANCHORING FIBRILS
SKIN TUMORS
INTRACELLULAR EXPRESSION
KINDLER-SYNDROME
MESSENGER-RNA
GROWTH-FACTOR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.det.2009.10.023

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title = "Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma",

abstract = "Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa associated squamous cell carcinoma.",

keywords = "Epidermolysis bullosa, Cancer, Metastasis, COL7A1, Type VII collagen, VII COLLAGEN EXPRESSION, XERODERMA-PIGMENTOSUM PATIENTS, BASEMENT-MEMBRANE, MATRIX METALLOPROTEINASES, ANCHORING FIBRILS, SKIN TUMORS, INTRACELLULAR EXPRESSION, KINDLER-SYNDROME, MESSENGER-RNA, GROWTH-FACTOR",

author = "South, {Andrew P.} and O'Toole, {Edel A.}",

year = "2010",

month = jan,

doi = "10.1016/j.det.2009.10.023",

language = "English",

volume = "28",

pages = "171--+",

journal = "Dermatologic Clinics",

issn = "0733-8635",

publisher = "W.B. Saunders",

number = "1",

}

TY - JOUR

T1 - Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

AU - South, Andrew P.

AU - O'Toole, Edel A.

PY - 2010/1

Y1 - 2010/1

N2 - Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa associated squamous cell carcinoma.

AB - Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa associated squamous cell carcinoma.

KW - Epidermolysis bullosa

KW - Cancer

KW - Metastasis

KW - COL7A1

KW - Type VII collagen

KW - VII COLLAGEN EXPRESSION

KW - XERODERMA-PIGMENTOSUM PATIENTS

KW - BASEMENT-MEMBRANE

KW - MATRIX METALLOPROTEINASES

KW - ANCHORING FIBRILS

KW - SKIN TUMORS

KW - INTRACELLULAR EXPRESSION

KW - KINDLER-SYNDROME

KW - MESSENGER-RNA

KW - GROWTH-FACTOR

U2 - 10.1016/j.det.2009.10.023

DO - 10.1016/j.det.2009.10.023

M3 - Article

C2 - 19945632

SN - 0733-8635

VL - 28

SP - 171-+

JO - Dermatologic Clinics

JF - Dermatologic Clinics

IS - 1

ER -

Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

Abstract

Keywords

UN SDGs

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