Understanding the Pathogenesis of Recessive Dystrophic Epidermolysis Bullosa Squamous Cell Carcinoma

Andrew P. South, Edel A. O'Toole

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    24 Citations (Scopus)

    Abstract

    Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa associated squamous cell carcinoma.

    Original languageEnglish
    Pages (from-to)171-+
    Number of pages9
    JournalDermatologic Clinics
    Volume28
    Issue number1
    DOIs
    Publication statusPublished - Jan 2010

    Keywords

    • Epidermolysis bullosa
    • Cancer
    • Metastasis
    • COL7A1
    • Type VII collagen
    • VII COLLAGEN EXPRESSION
    • XERODERMA-PIGMENTOSUM PATIENTS
    • BASEMENT-MEMBRANE
    • MATRIX METALLOPROTEINASES
    • ANCHORING FIBRILS
    • SKIN TUMORS
    • INTRACELLULAR EXPRESSION
    • KINDLER-SYNDROME
    • MESSENGER-RNA
    • GROWTH-FACTOR

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